{
  "abstract": "Background and Importance Suspected adverse drug reactions (sADRs) represent a significant cause of Emergency Department (ED) visits and hospitalisations, with a significant clinical and economic impact. Continuous investigation of sADRs enables the identification of risk patterns, particularly in high-risk populations, due to age or polypharmacy.Aim and Objectives To describe the characteristics of sADRs leading to ED visits in a University Hospital and to identify high-risk populations as potential targets for pharmacist interventions.Material and Methods All sADR reports submitted by the ED to the National Pharmacovigilance Network from January 2023 to July 2025, involving adult patients, were analysed. Data included age, sex, suspected drugs, PT Terms, seriousness, causality (Naranjo algorithm), hospitalisation, polypharmacy (≥5 medications), and potential inappropriateness (Beers Criteria for ≥65 years). Categorical variables were expressed as frequencies and percentages; continuous variables as means and standard deviations.Results 416 reports were identified, accounting for a total of 712 sADRs. Patients‘ mean age was 61±21 years; 207 patients (50%) were ≥65 years old, and 57% were female. 287 sADRs (40%) were classified as serious, and causality was assessed as probable in 64% and as possible in 36% of serious sADRs. The most commonly suspected drugs were amoxicillin/clavulanate, amoxicillin, rivaroxaban, apixaban and ibuprofen; most frequent PT terms included allergic reactions, haemorrhage, nausea and rectorrhagia. Regarding high-risk populations, 72 patients (17%), accounting for a total of 132 sADRs (19%), required hospitalisation; of these, 107 sADRs (81%) were classified as serious. Among hospitalised cases, 48 (12%) were on polypharmacy, while 16 (4%) were ≥65 years old with potentially inappropriate medications according to Beers Criteria. Causality assessment for sADRs related to polypharmacy and potentially inappropriate medications was probable in 36% and 35%, and possible in 64% and 65% of serious cases, respectively. The most commonly suspected drugs involved were rivaroxaban, warfarin and dabigatran, while the most frequent PT terms included cerebral haemorrhage, rectorrhagia, melena.Conclusion and Relevance Characterisation of ED sADRs was essential to detect high-risk populations as possible targets for pharmacist interventions. Approximately 16% of all ED sADRs requiring hospitalisation (12% related to polypharmacy and 4% to potentially inappropriate prescriptions) could represent potential targets for such interventions. Anticoagulants would be the main drug class to attention.Conflict of Interest No conflict of interest",
  "authors": [
    {
      "affiliations": [
        "University of Padua, Department of Pharmaceutical and Pharmacological Sciences, Padua, Italy"
      ],
      "name": "A Cadore"
    },
    {
      "affiliations": [
        "Azienda Ospedale – Università Padova, Projects and Clinical Research Unit, Padua, Italy"
      ],
      "name": "R Durighetto"
    },
    {
      "affiliations": [
        "Azienda Ospedale – Università Padova, Hospital Pharmacy Unit, Padua, Italy"
      ],
      "name": "L Camuffo"
    },
    {
      "affiliations": [
        "Azienda Ospedale – Università Padova, Hospital Pharmacy Unit, Padua, Italy"
      ],
      "name": "S Faoro"
    },
    {
      "affiliations": [
        "University of Padua, Department of Medicine, Padua, Italy"
      ],
      "name": "N Ferri"
    },
    {
      "affiliations": [
        "Azienda Ospedale – Università Padova, Hospital Pharmacy Unit, Padua, Italy"
      ],
      "name": "F Venturini"
    }
  ],
  "title": "4CPS-294 Suspected adverse drug reactions in the emergency setting: analysis for identification of high risk populations as possible targets for pharmacist intervention",
  "uid": "4f7306ad-d5c2-59a6-82ce-644d42686981"
}