{
  "abstract": "Background and Importance Vitamin D plays a crucial role in calcium and phosphorus homeostasis, bone metabolism, immune regulation and overall metabolic health. Hospitalised patients are particularly susceptible to deficiency due to limited sunlight exposure, hepatic and renal dysfunction and inadequate nutritional intake.Aim and Objectives This study aimed to assess baseline and follow-up vitamin D levels in patients receiving parenteral nutrition (PN) containing 200 IU of ergocalciferol, in order to identify deficiencies and establish supplementation protocols.Material and Methods A retrospective, observational, single-centre study was conducted in a tertiary care hospital during 2024. All adult inpatients treated with PN who had at least one vitamin D measurement were included. The variables collected from the electronic prescription software were: demographic, anthropometric and analytic variables, PN formulation and duration and additional oral or parenteral supplementation of vitamin D.Vitamin D deficiency was classified according to the 2022 ESPEN micronutrient guidelines, as mild (<20 ng/mL) or severe (<12 ng/mL) based on plasma 25-hydroxyvitamin D concentrations.Position measures were used for quantitative variables and number and percentage for qualitative variables.Results 57 patients were included (27 females, 47.4%), with a median age of 70 years, a median BMI of 23.1 kg/m 2, and a median PN duration of 19.4 days. Eight patients were excluded due to inappropriate measurement of vitamin D levels. Among 49 evaluable patients, the median 25-hydroxyvitamin D levels was 12.7 ng/ml, 79.6% of the patients presented mild (43.6%) or severe (56.4%) deficiency, while only 23% of them received additional supplementation.Vitamin D levels were monitored during PN in 38.6% of the cases. At the weaning off PN, only one patient with baseline deficiency achieved levels above 20 ng/ml. Among those with adequate baseline levels, five developed new-onset deficiency during PN treatment (two severe, three mild), which could be a sign of insufficient supply.Conclusion and Relevance Vitamin D deficiency was highly prevalent among PN patients reflecting an inadequate supply. The vitamin D content of current PN formulations seems insufficient to meet clinical requirements. The implementation of standardised supplementation and monitoring protocols is therefore crucial to optimise patient management and prevent deficiency. Early assessment and proactive correction are necessary to improve patient outcomes.Conflict of Interest No conflict of interest",
  "authors": [
    {
      "affiliations": [
        "Hospital General De Catalunya, Pharmacy, Sant Cugat Del Vallés, Spain"
      ],
      "name": "A Valenzuela Puig"
    },
    {
      "affiliations": [
        "Hospital General De Catalunya, Pharmacy, Sant Cugat Del Vallés, Spain"
      ],
      "name": "I Garcia Del Valle"
    },
    {
      "affiliations": [
        "Hospital General De Catalunya, Pharmacy, Sant Cugat Del Vallés, Spain"
      ],
      "name": "MA Perez Quiros"
    },
    {
      "affiliations": [
        "Hospital General De Catalunya, Pharmacy, Sant Cugat Del Vallés, Spain"
      ],
      "name": "M Blazquez Vidal"
    },
    {
      "affiliations": [
        "Hospital General De Catalunya, Pharmacy, Sant Cugat Del Vallés, Spain"
      ],
      "name": "M Ruiz Rey"
    },
    {
      "affiliations": [
        "Hospital General De Catalunya, Pharmacy, Sant Cugat Del Vallés, Spain"
      ],
      "name": "A Sin Martinez"
    },
    {
      "affiliations": [
        "Hospital General De Catalunya, Pharmacy, Sant Cugat Del Vallés, Spain"
      ],
      "name": "S Cortes Lopez"
    },
    {
      "affiliations": [
        "Hospital General De Catalunya, Pharmacy, Sant Cugat Del Vallés, Spain"
      ],
      "name": "G Morla Clavero"
    },
    {
      "affiliations": [
        "Hospital General De Catalunya, Pharmacy, Sant Cugat Del Vallés, Spain"
      ],
      "name": "P Marcos Pascua"
    },
    {
      "affiliations": [
        "Hospital General De Catalunya, Pharmacy, Sant Cugat Del Vallés, Spain"
      ],
      "name": "M Sanmartin Suñer"
    }
  ],
  "title": "5PSQ-162 Are we meeting the vitamin D requirements of our patients through parenteral nutrition?",
  "uid": "37075fef-1073-54f7-a4fa-eb73f0d72259"
}