{
  "abstract": "Background and Importance Dosage calculation errors involving high alert drugs are a significant cause of severe adverse drug events in paediatric and neonatal populations.Aim and Objectives To develop Paediatric High Alert Drugs Calculator Mobile Application (PMA), a specialised mobile application engineered to ensure dosing accuracy and medication safety.Material and Methods A multi-phase study was conducted. Phase1, a retrospective cohort study of infants admitted to the NICU of tertiary care hospital. The neonatal pharmacist participants on medication errors (ME) in pre- and post-ward-based settings were performed over a year. The incidence, severity, and type (95% CI) of ME were estimated for pre-post comparison. Descriptive statistics and inferential statistics were used to analyse the data. Phase 2, the empirical data and error patterns identified in Phase 1 served as the foundational evidence base for the architectural design and development of the PMA mobile application, Version 1.0. Phase 3, Implementation; Phase 4, a formal analysis of PMA Version 1.0’s utility, adoption, and impact was conducted. Phase 5, the strategic development of PMA Version 2.0, incorporating user feedback and additional functionalities.Results Phase 1: The results of 410 patients (5,482 patients-day) in pre- pharmacist, and 449 patients (5,848 patients-day) in post-pharmacist. The incidence rate (per 1,000 patient-days) increased from 23.5 times to 72.7 times post ward-based neonatal pharmacist participation 49.1 times increase (95% CI 41.13–57.16, p < 0.001). The incidence rate ratio: 3.09, 95% CI 2.53-3.79. The incidence of ME after neonatal pharmacist participation was observed to increase from 71/410 (17.3%) to 132/449 (29.4%) (RR 1.70, 95% CI 1.31-2.19, p < 0.001). Phase 2-5: The implementation of the PMA application yielded a profound reduction in its primary target: high alert medication dosage calculation errors decreased from 23.97% to 0.09%. End-user satisfaction was exceptional, achieving a mean score of 4.7 on a 5-point Likert Scale, which is categorised as the ‘highest level’ of satisfaction (criteria: 4.21-5.00).Conclusion and Relevance The PMA application has proven to be a useful clinical tool that directly enhances the core competencies of physicians, pharmacists, and nurses engaged in medication safety. The advantage of a ward-based neonatal pharmacy is necessary to protect patients from harm and the consequences of ME.Conflict of Interest No conflict of interest",
  "authors": [
    {
      "affiliations": [
        "Acute Care Pharmacy Practice, Department of Pharmacy, Surat Thani, Thailand"
      ],
      "name": "T Raknoo"
    }
  ],
  "title": "4CPS-086 A multi-phase study on the development of a paediatric high alert drugs calculator mobile application on medication errors in neonatal and paediatric intensive care units",
  "uid": "27f32e98-400d-5c16-a612-f12a1d835186"
}