{
  "abstract": "Background and Importance In a University Hospital Centre preparing 70,000 injectable anticancer drugs per year, several recent exposure incidents revealed insufficient mastery of the internal procedure among healthcare professionals.Aim and Objectives This observation prompted a situational assessment aimed at evaluating knowledge and proposing appropriate actions to optimise the management of these incidents.Material and Methods An analysis of adverse events and materiovigilance reports published between January 2022 and July 2025 was conducted to identify incidents involving chemotherapy spills. Subsequently, a 1 month survey was carried out among nursing staff handling injectable anticancer drugs. The questionnaire (39 items) assessed their knowledge regarding risks and guidelines in the event of an incident, and collected their experiences, concerns, and needs.Results The 25 incidents reported during the study period were detected during the administration (n=18; 72%) and storage stages (n=7; 28%) in clinical units. Around 75% of incidents were related to defective packaging or administration devices, and 25% to human error. Twelve departments participated in the survey, providing 45 responses (84% nurses). Respondents handled chemotherapy at least weekly (67% daily), but only 24% reported knowing the appropriate recommendations for accidental spills, and 33% the related risks. Among the 18 professionals knowing the existence of an internal procedure, only 10 knew its location. Only 11% reported having received training on risks and none on incident management. Although infrequent, accidental exposure was feared by 64% of respondents, mainly due to perceived health risks and insufficient training. Most of them requested training on risks (89%) and incident management (98%), preferring video resources (64%), printed materials (58%), and oral presentations (56%). Overall, 46% expressed interest in simulation-based training. Eighty-seven percent requested a ready-to-use decontamination kit and a quick-reference sheet.Conclusion and Relevance These results were shared with nursing and pharmacy teams to reinforce safety awareness during administration and dispensing. Specific actions were defined to prevent and manage exposure incidents involving injectable anticancer drugs: reissuing the procedure, staff training and implementing decontamination kits including a quick-reference sheet. These measures will be led by a multidisciplinary team (nurse managers, pharmacists, oncologists) and evaluated subsequently. Involving healthcare professionals in this process is crucial to improve adherence and engagement with the targeted measures.Conflict of Interest No conflict of interest",
  "authors": [
    {
      "affiliations": [
        "Groupement Hospitalier Sud- Hospices Civils De Lyon, 69495, Pierre-Benite, France"
      ],
      "name": "M Ledard"
    },
    {
      "affiliations": [
        "Groupement Hospitalier Sud- Hospices Civils De Lyon, 69495, Pierre-Benite, France"
      ],
      "name": "R Kimbidima"
    },
    {
      "affiliations": [
        "Groupement Hospitalier Sud- Hospices Civils De Lyon, 69495, Pierre-Benite, France"
      ],
      "name": "MA Cerfon"
    },
    {
      "affiliations": [
        "Groupement Hospitalier Sud- Hospices Civils De Lyon, 69495, Pierre-Benite, France"
      ],
      "name": "A Cerutti"
    },
    {
      "affiliations": [
        "Groupement Hospitalier Sud- Hospices Civils De Lyon, 69495, Pierre-Benite, France"
      ],
      "name": "N Vantard"
    },
    {
      "affiliations": [
        "Groupement Hospitalier Sud- Hospices Civils De Lyon, 69495, Pierre-Benite, France"
      ],
      "name": "A Baudouin"
    },
    {
      "affiliations": [
        "Groupement Hospitalier Sud- Hospices Civils De Lyon, 69495, Pierre-Benite, France",
        "EA 3738 CICLY- UCBL1, 69921, Oullins, France"
      ],
      "name": "C Rioufol"
    },
    {
      "affiliations": [
        "Groupement Hospitalier Sud- Hospices Civils De Lyon, 69495, Pierre-Benite, France",
        "EA 3738 CICLY- UCBL1, 69921, Oullins, France"
      ],
      "name": "F Ranchon"
    }
  ],
  "title": "5PSQ-144 Exposure incidents involving injectable anticancer drugs in clinical units: current situation and prospects for improvement",
  "uid": "1cde7db7-81b8-52fb-8c80-83510b17f66b"
}