{
  "abstract": "Background and Importance Long-term antibiotic therapies require strong patient adherence to ensure efficacy and prevent bacterial resistance. Pharmaceutical consultations (PCs) were implemented to educate patients, address treatment-related concerns, and promote active involvement in home-based care.Aim and Objectives This study aimed to evaluate the impact of PCs on the management of patients receiving long-term (>14 days) antibiotic therapies.Material and Methods A prospective monocentric study was conducted from May 2024 to April 2025. Patients prescribed high risk antibiotics, identified by the infectious diseases mobile team, were referred to hospital pharmacists for a PC. Each patient received an antibiotic information leaflet and the pharmacist’s contact details. A satisfaction questionnaire was completed after the consultation. Data were collected and analysed using Microsoft Excel.Results A total of 40 PCs were conducted (70% male, median age: 76 years (Q1=59; Q3=79)). Most consultations occurred in surgical wards (45%) and emergency/post-emergency units (18%). The main infection sites were osteomyelitis (30%), endocarditis (18%), surgical site infections (15%), and abscesses (15%). The median antibiotic treatment duration was 39 days (Q1=21; Q3=42), with 65% monotherapies and 35% dual therapies, accounting for 54 prescribed antibiotics.The most frequently used antibiotics were sulfamethoxazole/trimethoprim (24%), levofloxacin (20%), and amoxicillin (19%). A total of 21 pharmaceutical interventions (PIs) were performed during the PCs, with a 90% acceptance rate by prescribers. These interventions mainly addressed the prevention or correction of drug interactions (eg, rifampicin with apixaban, levofloxacin with iron), the management of adverse effects (eg, renal or hepatic toxicity under cotrimoxazole), the optimisation of administration schedules (eg, rifampicin taken on an empty stomach), and adjustments to treatment duration or dosage, including for antibiotics and anticoagulants.Three patients contacted the hospital pharmacist after the PC: two for clarification on dosing or duration, and one to report a severe skin reaction to sulfamethoxazole/trimethoprim, leading to urgent rehospitalisation and treatment modification. Patient feedback indicated a high level of satisfaction.Conclusion and Relevance Pharmaceutical consultations enhance the safety and effectiveness of long-term antibiotic therapies by improving patient understanding, supporting adherence, and enabling timely intervention when complications arise. They underscore the essential role of hospital pharmacists in multidisciplinary infectious disease management.Conflict of Interest No conflict of interest",
  "authors": [
    {
      "affiliations": [
        "Centre Hospitalier D’argenteuil, Clinical Pharmacy, Argenteuil, France"
      ],
      "name": "M Questel"
    },
    {
      "affiliations": [
        "Centre Hospitalier D’argenteuil, Mobile Infectious Disease Team, Argenteuil, France"
      ],
      "name": "M Dubert"
    },
    {
      "affiliations": [
        "Centre Hospitalier D’argenteuil, Mobile Infectious Disease Team, Argenteuil, France"
      ],
      "name": "C Wemmert"
    },
    {
      "affiliations": [
        "Centre Hospitalier D’argenteuil, Mobile Infectious Disease Team, Argenteuil, France"
      ],
      "name": "C Humbert"
    },
    {
      "affiliations": [
        "Centre Hospitalier D’argenteuil, Clinical Pharmacy, Argenteuil, France"
      ],
      "name": "A Feral"
    },
    {
      "affiliations": [
        "Centre Hospitalier D’argenteuil, Clinical Pharmacy, Argenteuil, France"
      ],
      "name": "JL Pons"
    }
  ],
  "title": "4CPS-009 Pharmaceutical consultations and follow-up for long-term antibiotic therapies",
  "uid": "12d1be69-389c-564d-9bc6-a808f844ff19"
}