{
  "abstract": "Background and Importance Many drugs prescribed for immune-mediated diseases require refrigeration and are dispensed through the outpatient pharmacy for home administration, often covering 2 months of treatment. Exceptional situations, such as prolonged power outages, may compromise drug stability, causing patient concern and potential economic losses.Aim and Objectives To evaluate the economic impact of a 15-hour total power outage on the pharmacy consultation for immune-mediated diseases.Material and Methods A retrospective observational study was conducted including all patients who contacted the pharmacy after the blackout, seeking advice on the stability of refrigerated drugs (2-8°C) stored at home. For each patient, the following data were collected: sex, age, disease and dispensed drug.Patients were asked to identify the drug, check the refrigerator temperature (using a digital thermometer with memory), report the number of stored units and provide the date of the next administration.Drug stability was assessed by consulting the Summary of Product Characteristics and complementary data sources.Qualitative variables were expressed as percentages; quantitative variables as median and range.Results 49 patients were included (70% women), with a median age of 49 (9-90) years. Most cases corresponded to: Rheumatology (59%), Dermatology (33%) and Gastroenterology (8%). Rheumatoid arthritis was the most frequent diagnosis (30%).Drugs involved: adalimumab (35%), etanercept (25%), certolizumab (8%), belimumab (6%), ixekizumab (6%), secukinumab (6%), dupilumab (4%), tocilizumab (4%), abatacept (2%), risankizumab (2%) and sarilumab (2%).In 35% of cases, patients confirmed that their refrigerator maintained temperature during the outage. Patients stored a median of 3 (1-10) units at home.According to data consulted, most drugs remained stable for up to 14 days at room temperature, although some had shorter stability periods (belimumab, risankizumab, secukinumab or ixekizumab).Based on this, 82% of patients could safely use their medication. However, 43 units were discarded, 15 of them from 4 patients who had frozen the medication. This resulted in an estimated economic loss of €9.343. Advice on preventive measures was provided to all patients.Conclusion and Relevance Power outages can generate uncertainty about thermolabile drug stability and lead to substantial financial losses. Pharmacist counselling and patient education are essential to ensure safe administration, minimise drug wastage and protect both clinical outcomes and healthcare resources.Conflict of Interest No conflict of interest",
  "authors": [
    {
      "affiliations": [
        "Complejo Hospitalario Universitario De Pontevedra, Pharmacy, Pontevedra, Spain"
      ],
      "name": "S Caíña López"
    },
    {
      "affiliations": [
        "Complejo Hospitalario Universitario De Pontevedra, Pharmacy, Pontevedra, Spain"
      ],
      "name": "A Bartolomé Figueroa"
    },
    {
      "affiliations": [
        "Complejo Hospitalario Universitario De Pontevedra, Pharmacy, Pontevedra, Spain"
      ],
      "name": "AB Veiga Villaverde"
    },
    {
      "affiliations": [
        "Complejo Hospitalario Universitario De Pontevedra, Pharmacy, Pontevedra, Spain"
      ],
      "name": "C Crespo Diz"
    }
  ],
  "title": "4CPS-105 Economic impact of a power outage on the pharmacy consultation for immune-mediated diseases",
  "uid": "0f67020e-2dcb-5476-a9ef-cc378b9cb4c5"
}