{
  "abstract": "Background and Importance Mortality reduction observed with statin lipid-lowering therapy for secondary prevention is not observed in primary prevention in patients over 75 years of age. Adverse reacctions are dose-dependent and may be more significant in the elderly.Aim and Objectives Review statin treatment in institutionalised elderly patients to identify prescriptions that meet institucional deprescription program criteria.Material and Methods An observational, cross-sectional study on July 2023, including all patients over 75 years of age institutionalised in a public nursing home, who are receiving statin treatment.Demographic, clinical, and laboratory data were collected using the computerised prescription program and electronic medical records. Indications and treatment doses were reviewed. The institucional deprescription program criteria excluded patients with human immunodeficiency virus infection and those diagnosed with heterozygous familial hypercholesterolaemia. In patients with cardiovascular risk factors diagnosed with diabetes mellitus (DM) and/or arterial hypertension with chronic kidney disease (AHCKD), deprescription is not considered, but rather a reduction in therapy intensity.Results Were on statin treatment 65 patients: 11 patients under 75 years of age (16.9%) were excluded, so 54 patient treatment was reviewed, 39 women (72%) with a mean age of 87 years.Met the institucional deprescription criteria 20 of 54 reviewed patients (37%), all treatments indicated for primary prevention: 2 with high-intensity therapy, 9 with moderate-intensity, and 9 with low-intensity.In 26 of 34 patients (48.1%) due to cardiovascular risk factors, deprescription was not considered , but intensity reduction was. Were indicated for primary prevention 19 treatments: 4 high-intensity treatments (2 DM diagnosed and 2 DM with AHCKD) and 10 moderate-intensity treatments (2 DM diagnosed, 4 with AHCKD and 4 with both pathologies). Were indicated for secondary prevention 7 treatments: 2 moderate-intensity treatments (DM diagnosed, and DM with AHCKD diagnosed) and 5 high-intensity treatment (AHCKD diagnosed and one of them also with DM diagnosed).Conclusion and Relevance More than 30% of reviewed treatments were prescribed for the primary prevention of cardiovascular events due to hypercholesterolaemia, where there is no evidence that statins reduce mortality, myocardial infarctions, or strokes; so they were susceptible to deprescription. Deprescribing these statin treatments would reduce the risk of adverse effects and interactions, and improve patients‘ quality of life and system efficiency.Conflict of Interest No conflict of interest",
  "authors": [
    {
      "affiliations": [
        "Hospital El Bierzo, Hospital Pharmacy, León, Spain"
      ],
      "name": "E Martínez Álvarez"
    },
    {
      "affiliations": [
        "Hospital El Bierzo, Hospital Pharmacy, León, Spain"
      ],
      "name": "B De La Nogal Fernández"
    },
    {
      "affiliations": [
        "Hospital El Bierzo, Hospital Pharmacy, León, Spain"
      ],
      "name": "A Fernandez Cordon"
    },
    {
      "affiliations": [
        "Hospital El Bierzo, Hospital Pharmacy, León, Spain"
      ],
      "name": "R Martinez"
    },
    {
      "affiliations": [
        "Hospital Alvaro Cunqueiro, Hospital Pharmacy, Vigo, Spain"
      ],
      "name": "N Alvarez Nuñez"
    },
    {
      "affiliations": [
        "Hospital El Bierzo, Hospital Pharmacy, León, Spain"
      ],
      "name": "H Garcia Lagunar"
    },
    {
      "affiliations": [
        "Hospital El Bierzo, Hospital Pharmacy, León, Spain"
      ],
      "name": "ME Garcia Mayo"
    },
    {
      "affiliations": [
        "Hospital El Bierzo, Hospital Pharmacy, León, Spain"
      ],
      "name": "RM Gonzalez Franco"
    },
    {
      "affiliations": [
        "Hospital El Bierzo, Hospital Pharmacy, León, Spain"
      ],
      "name": "N Ferreras López"
    },
    {
      "affiliations": [
        "Hospital El Bierzo, Hospital Pharmacy, León, Spain"
      ],
      "name": "M Rodriguez Maria"
    }
  ],
  "title": "5PSQ-001 Statin potential deprestscription in institutionalised elderly patients",
  "uid": "031a3604-a7d7-52b2-8633-298f02bef93b"
}