{
  "abstract": "Thrombotic microangiopathy is a serious condition that can be precipitated by exposure to certain medications. Although rare, it is life threatening and requires a high index of clinical suspicion, appropriate laboratory testing and immediate cessation of the offending agent. We present a case of a 75-year-old man with a history of ischaemic heart disease treated with clopidogrel and aspirin. One month after initiating the treatment he developed microangiopathic haemolytic anaemia and thrombocytopenia. Extensive clinical and laboratory investigations suggested thrombotic microangiopathy secondary to clopidogrel. The drug was immediately discontinued and treatment with intravenous corticosteroids was started. Within a week the patient’s laboratory parameters normalised, indicating successful recovery. This case highlights the role of early detection and immediate discontinuation of suspected medication in the effective management of clopidogrel-induced thrombotic microangiopathy. Healthcare professionals should consider drug-induced thrombotic microangiopathy as a possible diagnosis in patients receiving clopidogrel who present with thrombocytopenia and microangiopathic haemolytic anaemia.",
  "authors": [
    {
      "affiliations": [
        "Pharmacy Department, Division of Medicines, Hospital Clínic de Barcelona, Barcelona, Spain"
      ],
      "name": "Thais Lizondo López"
    },
    {
      "affiliations": [
        "Pharmacy Department, Hospital Universitari de Vic, Barcelona, Spain"
      ],
      "name": "Aina Font i Barceló"
    },
    {
      "affiliations": [
        "Medical Intensive Care Unit, Hospital Clínic de Barcelona",
        "IDIBAPS, University of Barcelona, Barcelona, Spain"
      ],
      "name": "Carlos García Gutiérrez"
    },
    {
      "affiliations": [
        "Nephrology and Kidney Transplant Department, National Reference Center for Complex Glomerular Diseases (CSUR), Hospital Clínic de Barcelona, Barcelona, Spain",
        "Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain"
      ],
      "name": "Miquel Blasco"
    },
    {
      "affiliations": [
        "Medical Intensive Care Unit, Hospital Clínic de Barcelona",
        "IDIBAPS, University of Barcelona, Barcelona, Spain",
        "Medical Oncology Department, Hospital Clínic de Barcelona-IDIBAPS, Barcelona, Spain"
      ],
      "name": "Ignacio Grafia"
    },
    {
      "affiliations": [
        "Pharmacy Department, Division of Medicines, Hospital Clínic de Barcelona, Barcelona, Spain"
      ],
      "name": "Carla Bastida"
    },
    {
      "affiliations": [
        "Medical Intensive Care Unit, Hospital Clínic de Barcelona",
        "IDIBAPS, University of Barcelona, Barcelona, Spain"
      ],
      "name": "Pedro Castro-Rebollo"
    },
    {
      "affiliations": [
        "Pharmacy Department, Division of Medicines, Hospital Clínic de Barcelona, Barcelona, Spain"
      ],
      "name": "Dolors Soy-Muner"
    }
  ],
  "title": "Clopidogrel-induced thrombotic microangiopathy: a case report",
  "uid": "cf1f7def-04f7-5fda-bf98-361831f5dcdf"
}