{
  "abstract": "Differences of sex development (DSD) comprise a heterogeneous group of congenital conditions affecting urogenital and reproductive development. Variations in sex determination can cause a mismatch between chromosomal, gonadal and phenotypic sex, leading to atypical internal and/or external genitalia. Presentations are varied and most commonly occur in the newborn period and during adolescence. Clinical care is complex and diagnostic pathways may be protracted. Decisions around sex assignment carry ethical considerations and can place a considerable psychological burden on families.This 15-minute guide summarises a practical, stepwise approach for general paediatric and neonatal teams: when to suspect DSD, how to examine and communicate, the first-line investigations to initiate, when/how to escalate to the multidisciplinary DSD service, and how to support families.",
  "authors": [
    {
      "affiliations": [
        "Department of Paediatric Endocrinology, Bristol Royal Hospital for Children, Bristol, UK"
      ],
      "name": "Danielle Eddy"
    },
    {
      "affiliations": [
        "Department of Paediatric Endocrinology and Diabetes, Birmingham Women's and Children’s NHS Foundation Trust, Birmingham, UK"
      ],
      "name": "Chariklia Pieridou"
    },
    {
      "affiliations": [
        "Department of Paediatric Endocrinology and Diabetes, Birmingham Women's and Children’s NHS Foundation Trust, Birmingham, UK",
        "Birmingham Children’s Hospital Institute of Child Health, Birmingham, UK"
      ],
      "name": "Eman Kamaleldeen"
    },
    {
      "affiliations": [
        "Department of Paediatric Endocrinology, Bristol Royal Hospital for Children, Bristol, UK"
      ],
      "name": "Julie Alderson"
    },
    {
      "affiliations": [
        "Department of Paediatric Endocrinology, Bristol Royal Hospital for Children, Bristol, UK"
      ],
      "name": "Rachel Caddick"
    },
    {
      "affiliations": [
        "dsdFamilies, Charitable Organisation, UK"
      ],
      "name": "Joanne Williams"
    },
    {
      "affiliations": [
        "Charitable Organisation, -, UK"
      ],
      "name": "dsdFamilies"
    },
    {
      "affiliations": [
        "Department of Paediatric Endocrinology and Diabetes, Birmingham Women's and Children’s NHS Foundation Trust, Birmingham, UK"
      ],
      "name": "Zainaba Mohamed"
    },
    {
      "affiliations": [
        "Department of Paediatric Endocrinology, Bristol Royal Hospital for Children, Bristol, UK",
        "University of Bristol, Bristol, UK"
      ],
      "name": "Dinesh Giri"
    }
  ],
  "title": "Fifteen-minute consultation: A family-centred approach to recognising and managing differences in sex development",
  "uid": "2cd40355-b8d1-5cae-b43b-68838ceac215"
}