{
  "abstract": "Paediatricians across many specialities and pharmacists are increasingly being asked to prescribe, or jointly look after, children treated with mammalian target of rapamycin (mTOR) inhibitors (eg, sirolimus and everolimus). There is an expanding list of conditions including tuberous sclerosis and vascular malformations where treatment with mTOR inhibitors may help. This brief practice pointer summarises the practical steps before starting these treatments, what potential side effects to discuss with families and what monitoring arrangements should be put in place.",
  "authors": [
    {
      "affiliations": [
        "Department of Paediatric Nephrology, Great North Children's Hospital, Newcastle upon Tyne, UK",
        "Newcastle University Faculty of Medical Sciences, Newcastle upon Tyne, UK"
      ],
      "name": "Yincent Tse"
    },
    {
      "affiliations": [
        "Pharmacy, Newcastle upon Tyne Hospital NHS Trust, Newcastle upon Tyne, UK"
      ],
      "name": "Nicola Vasey"
    },
    {
      "affiliations": [
        "Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK",
        "Department of Neurology, Royal Victoria Infirmary, Newcastle upon Tyne, UK"
      ],
      "name": "Rhys Thomas"
    },
    {
      "affiliations": [
        "Department of Dermatology, Newcastle upon Tyne Hospital NHS Trust, Newcastle upon Tyne, UK"
      ],
      "name": "Suzy Leech"
    },
    {
      "affiliations": [
        "Paediatric Immunology and Infectious Diseases, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK",
        "Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK"
      ],
      "name": "Stephen Owens"
    },
    {
      "affiliations": [
        "Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK",
        "NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne, UK"
      ],
      "name": "John Sayer"
    }
  ],
  "title": "How to use mTOR inhibitors in children",
  "uid": "71569773-f720-50fd-a8d8-f6d2993f92da"
}