{
  "abstract": "We are undertaking two interrelated research initiatives aimed at evaluating the efficacy of cancer screening programs from both national and international viewpoints. The first initiative, a systematic review, rigorously examines the impact of UK cancer screening programs on the incidence and mortality of metastatic cancers such as breast, cervical, and bowel cancers. Simultaneously, our second initiative, a scoping review, broadens the scope to a global scale. This review aims to comprehensively map the existing body of research on the efficacy of cancer screening worldwide, pinpointing prevalent research gaps and variations across different regions and healthcare systems, including the implications of over-diagnosis on a global scale. Collectively, these studies seek to provide a holistic view of the current landscape of cancer screening and its outcomes. We aim to present the findings of both reviews at the forthcoming conference, thereby enriching the discourse on cancer prevention strategies globally by integrating localised insights with broader international trends.Abstract for: Systematic Review on Cancer Screening and Metastatic Cancer Incidence in the UKTitle: Evaluating the Impact of UK Cancer Screening Programs on Metastatic Cancer Incidence: A Systematic ReviewBackground The aim of screening is to detect cancers destined to metastasise, at an earlier, more treatable stage. If screening successfully identifies cancers prone to becoming metastatic, then the rate of cancers first diagnosed at an advanced stage should decrease following the implementation of screening programs. Conversely, if the incidence of metastatic cancer remains unchanged after screening is introduced, this could indicate that the screening is ineffective and may be leading to over-diagnosis.Objective for Systematic Review This systematic review aims To review the existing evidence on the effectiveness of UK national screening programmes in reducing the incidence of metastatic cancer.Methods for Systematic Review This ongoing review systematically searches databases such as MEDLINE, Embase, and the Cochrane Library, focusing on studies from the year 2000 onwards. By applying stringent inclusion and exclusion criteria, this review meticulously evaluates studies that report on the incidence and mortality of metastatic cancer related to breast, cervical, and bowel cancer screenings.Expected Results for Systematic Review The review preliminarily suggests potential quantitative changes in the incidence of metastatic cancer since the introduction of screening programs. While complete and detailed results will be presented at the conference, early findings indicate a variable impact of screening across different cancer types, with preliminary estimates suggesting a potential reduction in the incidence of advanced-stage cancers in some contexts. These initial insights will contribute to ongoing discussions on the efficacy of screening programs and guide future research orientations.Conclusion for Systematic Review Complete results and detailed analysis will be presented at the conference, contributing to policy discussions and future research orientations.Abstract for: Scoping Review on the Effectiveness of Global Cancer Screening ProgramsTitle: Mapping the Global Effectiveness of Cancer Screening Programs in Reducing Metastatic Cancer Incidence and Mortality: A Scoping ReviewBackground Global disparities in cancer screening effectiveness necessitate a comprehensive understanding of how these programs impact metastatic cancer incidence and mortality worldwide, including the critical issue of over-diagnosis.Objective for Scoping Review This scoping review aims to map the breadth and depth of evidence on the effectiveness of cancer screening programs globally, focusing on their role in reducing metastatic cancer outcomes and exploring the prevalence of over-diagnosis.Methods for Scoping Review Utilising a broad range of sources, including MEDLINE, Embase, and grey literature, this review adopts a meticulous approach to charting data across diverse geopolitical and healthcare contexts.Expected Results for Scoping Review The review will provide a panoramic view of the existing literature, identifying prevalent trends, significant evidence gaps, and the varying impact of screening programs in different regions.Conclusion for Scoping Review Complete results and detailed analysis will be presented at the conference, contributing to policy discussions and future research orientations.",
  "authors": [
    {
      "affiliations": [
        "Oxford University, Oxford, UK"
      ],
      "name": "Lynda Godenzi"
    },
    {
      "affiliations": [
        "Oxford University, Oxford, UK"
      ],
      "name": "Carl Heneghan"
    },
    {
      "affiliations": [
        "Oxford University, Oxford, UK"
      ],
      "name": "Jason Oke"
    }
  ],
  "title": "089 1) Evaluating the impact of UK cancer screening programs on metastatic cancer incidence: a systematic review 2) Mapping the global effectiveness of cancer screening programs in reducing metastatic cancer incidence and mortality: a scoping review",
  "uid": "f4220afa-fdd7-58ee-8a83-df57607cdfad"
}