{
  "abstract": "Many pains encountered in palliative care result from multiple pain mechanisms, eg, cancer pain may include inflammatory, bony, neuropathic, myofascial and/or visceral components. Not all such pains respond fully to opioids. Opioid-poorly-responsive pain (OPRP) is treated with non-opioid analgesics selected according to pain mechanism(s), tolerability and comorbidities. Conventionally, such analgesics are given via sequential trials one at a time (serial monotherapy, SMT). But SMT takes time; several treatment trials may be required before pain is satisfactorily controlled. Thus, faster selection methods are desirable.",
  "authors": [
    {
      "affiliations": [
        "Earl Mountbatten Hospice, Newport, Isle of Wight, UK",
        "Palliative Care Team, St Mary’s Hospital NHS Trust, Newport, Isle of Wight, UK"
      ],
      "name": "Paul Howard"
    },
    {
      "affiliations": [
        "Department of Palliative Medicine, Marymount University Hospital and Hospice, Cork, Ireland",
        "Department of Palliative Medicine, Cork University Hospital, Cork, Ireland"
      ],
      "name": "John Curtin"
    }
  ],
  "title": "Polyanalgesic titration for severe refractory pain",
  "uid": "60305385-caa6-5157-b5ae-08279f5427e4"
}