{
  "abstract": "Objective This study investigates the interaction between depression, immunity, and 5-HTTLPR among colorectal cancer (CRC) patients.Methods This prospective longitudinal study collected information on depression and lymphocyte percentages at two time points: the first cycle and the final cycles of FOLFOX chemotherapy. Clinical depression was assessed using the HADS-D score. Genotyping identified 5-HTTLPR alleles. The dependent variables were changes in the percentages of CD4+, CD8+, CD19+, and CD16/56+ lymphocytes.Results Among 104 patients, no significant direct associations were observed between changes in lymphocyte percentages and HADS-D scores. However, with the interaction of 5-HTTLPR polymorphism, the moderated regression analysis revealed two significant associations between HADS-D scores and changes in the percentages of CD4+ and CD16/56+ lymphocytes.Conclusion Changes in the percentage of CD4+ cells and CD16/56+ cells under depression were moderated by 5-HTTLPR alleles among CRC patients undergoing FOLFOX chemotherapy, suggesting a gene-environment interaction.",
  "authors": [
    {
      "affiliations": [
        "Department of psychiatry, School of Medicine, Chonnam National University, Korea",
        "Mental Health Clinic, Chonnam National University Hwasun Hospital, Korea"
      ],
      "name": "Seon Young Kim"
    }
  ],
  "title": "G-3 The impact of 5-HTTLPR polymorphism on depression and lymphocyte changes in colorectal cancer patients",
  "uid": "b0c35cff-6847-530f-9326-349d3b52491e"
}