{
  "abstract": "Objective To examine the prevalence of thiamine deficiency and its potential risk factors in cancer outpatients.Methods A cross-sectional study of cancer outpatients aged ≥20 years at a regional hospital in Kyoto, Japan (January–February 2022). Thiamine deficiency was defined as ≤23 ng/mL by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Multivariable logistic regression was used to estimate ORs and 95% CIs for potential risk factors for thiamine deficiency.Results A total of 106 patients were included in this study (mean age 68.3 years, 61% female). Of the 106 patients, 27 (25.5%) had low thiamine levels despite the absence of recognised deficiency symptoms. In multivariable logistic regression analysis, the adjusted OR was 4.05 (95% CI 0.88 to 18.60).Conclusions The prevalence of thiamine deficiency was 25.5% among cancer outpatients without recognised symptoms. An association between low dietary intake and thiamine deficiency was suggested, though further large-scale studies are needed to confirm risk factors and guide management strategies.",
  "authors": [
    {
      "affiliations": [
        "Department of Medical Oncology and Palliative Care, Mitsubishi Kyoto Hospital, Kyoto, Japan"
      ],
      "name": "Akira Yoshioka"
    },
    {
      "affiliations": [
        "Departments of Psycho-Oncology, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan"
      ],
      "name": "Mayumi Ishida"
    },
    {
      "affiliations": [
        "Department of Supportive Care Medicine, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan"
      ],
      "name": "Nozomu Uchida"
    },
    {
      "affiliations": [
        "Departments of Psycho-Oncology, Saitama Medical University International Medical Center, Hidaka, Japan"
      ],
      "name": "Hideki Onishi"
    },
    {
      "affiliations": [
        "Department of Clinical Epidemiology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"
      ],
      "name": "Izumi Sato"
    }
  ],
  "title": "Thiamine deficiency in outpatients at a regional cancer centre in Japan: cross-sectional observational study",
  "uid": "3ae0672d-3a67-50b7-bfdd-69a74f575f2d"
}