{
  "abstract": "Objectives To describe longitudinal changes in quality of life (QOL) and symptoms among patients with acute myeloid leukaemia (AML) receiving real-world early palliative care (EPC) during the first year after diagnosis.Methods This prospective observational study enrolled consecutive adults with AML followed in an outpatient EPC clinic. QOL and symptoms were assessed monthly using the Functional Assessment of Cancer Therapy–Leukemia (FACT-Leu), the Edmonton Symptom Assessment Scale (ESAS) and the Hospital Anxiety and Depression Scale (HADS). Scores were analysed through joint modelling, integrating longitudinal and survival data, and sensitivity analyses.Results Thirty-eight patients contributed 169 FACT-Leu, 151 ESAS and 111 HADS questionnaires. From baseline, median FACT-Leu scores improved from 108.7 to 135.7 at 4 months and remained stable through 8 and 12 months (p≤0.011), while ESAS scores decreased from 25.2 to 5.7 by 4 months and remained low through 12 months (p<0.001), indicating sustained symptom improvement. HADS scores showed no statistically significant changes, although a modest anxiety improvement was noted. Trajectories remained consistent across all sensitivity analyses.Conclusions In AML patients receiving EPC in a real-world outpatient setting, QOL and symptom burden showed sustained improvement over time. These descriptive findings highlight the potential effectiveness and clinical relevance of EPC in routine AML care and provide real-world reference data for future controlled studies.",
  "authors": [
    {
      "affiliations": [
        "Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy",
        "Azienda Ospedaliera Universitaria di Modena, Hematology Unit and Chair, Modena, Italy"
      ],
      "name": "Leonardo Potenza"
    },
    {
      "affiliations": [
        "Azienda Ospedaliera Universitaria di Modena, Hematology Unit and Chair, Modena, Italy"
      ],
      "name": "Davide Giusti"
    },
    {
      "affiliations": [
        "Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy"
      ],
      "name": "Eleonora Borelli"
    },
    {
      "affiliations": [
        "Azienda Ospedaliera Universitaria di Modena, Hematology Unit and Chair, Modena, Italy"
      ],
      "name": "Elisabetta Colaci"
    },
    {
      "affiliations": [
        "Azienda Ospedaliera Universitaria di Modena, Hematology Unit and Chair, Modena, Italy"
      ],
      "name": "Francesco Morandi"
    },
    {
      "affiliations": [
        "Medical and Surgical Sciences, University of Modena and Reggio Emilia, Statistics Unit, Modena, Italy"
      ],
      "name": "Riccardo Cuoghi Costantini"
    },
    {
      "affiliations": [
        "Medical and Surgical Sciences, University of Modena and Reggio Emilia, Statistics Unit, Modena, Italy"
      ],
      "name": "Cinzia Del Giovane"
    },
    {
      "affiliations": [
        "Azienda Ospedaliera Universitaria di Modena, Hematology Unit and Chair, Modena, Italy"
      ],
      "name": "Fabio Forghieri"
    },
    {
      "affiliations": [
        "Azienda Ospedaliera Universitaria di Modena, Hematology Unit and Chair, Modena, Italy"
      ],
      "name": "Monica Morselli"
    },
    {
      "affiliations": [
        "Azienda Ospedaliera Universitaria di Modena, Hematology Unit and Chair, Modena, Italy"
      ],
      "name": "Francesca Bettelli"
    },
    {
      "affiliations": [
        "Azienda Ospedaliera Universitaria di Modena, Hematology Unit and Chair, Modena, Italy"
      ],
      "name": "Valeria Pioli"
    },
    {
      "affiliations": [
        "Azienda Ospedaliera Universitaria di Modena, Hematology Unit and Chair, Modena, Italy"
      ],
      "name": "Angela Cuoghi"
    },
    {
      "affiliations": [
        "Azienda Ospedaliera Universitaria di Modena, Hematology Unit and Chair, Modena, Italy"
      ],
      "name": "Paola Bresciani"
    },
    {
      "affiliations": [
        "Azienda Ospedaliera Universitaria di Modena, Hematology Unit and Chair, Modena, Italy"
      ],
      "name": "Andrea Messerotti"
    },
    {
      "affiliations": [
        "Azienda Ospedaliera Universitaria di Modena, Hematology Unit and Chair, Modena, Italy"
      ],
      "name": "Andrea Gilioli"
    },
    {
      "affiliations": [
        "Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy",
        "Azienda Ospedaliera Universitaria di Modena, Hematology Unit and Chair, Modena, Italy"
      ],
      "name": "Roberto Marasca"
    },
    {
      "affiliations": [
        "Azienda Ospedaliera Universitaria di Modena, Hematology Unit and Chair, Modena, Italy"
      ],
      "name": "Luca Cassanelli"
    },
    {
      "affiliations": [
        "Azienda Ospedaliera Universitaria di Modena, Hematology Unit and Chair, Modena, Italy"
      ],
      "name": "Angelica Parisotto"
    },
    {
      "affiliations": [
        "Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy",
        "Azienda Ospedaliera Universitaria di Modena, Hematology Unit and Chair, Modena, Italy"
      ],
      "name": "Federica Cretì"
    },
    {
      "affiliations": [
        "Oncology and Palliative Care Units, Civil Hospital Carpi, USL, Modena, Italy, Carpi (MO), Italy"
      ],
      "name": "Claudia Mucciarini"
    },
    {
      "affiliations": [
        "Department of Linguistic Sciences and Foreign Literatures, Catholic University of the Sacred Heart, Milano, Lombardia, Italy"
      ],
      "name": "Sarah Bigi"
    },
    {
      "affiliations": [
        "Medical and Surgical Sciences, University of Modena and Reggio Emilia, Statistics Unit, Modena, Italy"
      ],
      "name": "Roberto D’Amico"
    },
    {
      "affiliations": [
        "Data Center and Health Outcomes Research Unit, Italian Group for Adult Hematologic Diseases (GIMEMA), Rome, Italy"
      ],
      "name": "Fabio Efficace"
    },
    {
      "affiliations": [
        "Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA"
      ],
      "name": "Oreofe Odejide"
    },
    {
      "affiliations": [
        "Palliative Care & Rehabilitation Medicine, UT MD Anderson Cancer Center, Houston, Texas, USA"
      ],
      "name": "Eduardo Bruera"
    },
    {
      "affiliations": [
        "Supportive Care, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada",
        "Medicine, University of Toronto, Toronto, Ontario, Canada"
      ],
      "name": "Camilla Zimmermann"
    },
    {
      "affiliations": [
        "Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy",
        "Azienda Ospedaliera Universitaria di Modena, Hematology Unit and Chair, Modena, Italy"
      ],
      "name": "Mario Luppi"
    },
    {
      "affiliations": [
        "Oncology and Palliative Care Units, Civil Hospital Carpi, USL, Modena, Italy, Carpi (MO), Italy"
      ],
      "name": "Elena Bandieri"
    }
  ],
  "title": "Quality of life and symptoms in acute myeloid leukaemia with early palliative care: real-world observational study",
  "uid": "b78bd081-bdc8-534b-9517-d5f164303bd8"
}