{
  "abstract": "Chronic limb-threatening ischaemia (CLTI) is characterised by ischaemic rest pain lasting more than 2 weeks and non-healing wounds. Ischaemic rest pain is the result of a complex pathophysiological process, with nociceptive and neuropathic components. Over time, peripheral and central sensitisation occurs, likely linked to the activation of N-methyl-D-aspartate (NMDA) receptors. 1 Pain worsens and becomes increasingly difficult to control.",
  "authors": [
    {
      "affiliations": [
        "Saint Andrew's Community Hospital, Singapore"
      ],
      "name": "Chloe Hui-Ling Choy"
    },
    {
      "affiliations": [
        "Changi General Hospital, Singapore"
      ],
      "name": "King Jane Ong"
    }
  ],
  "title": "Ketamine for chronic limb-threatening ischaemia pain",
  "uid": "0a689826-b28e-5ab3-b972-fb1a56fdc926"
}