{
  "abstract": "Objectives This study investigated the muscle fat fraction (FF) and muscle-related parameters before and after allogeneic hematopoietic stem cell transplantation (HSCT).Methods Fat and water signals were derived from the in-phase and out-of-phase MR signal intensities of the pelvis and thigh using the two-point Dixon technique. They were analysed using Synapse Vincent, and muscle quality was evaluated using the FF. The muscle mass was assessed by measuring the thigh and gluteal muscle areas using a manual trace on the MR image. The association between the muscle FF and clinical data was retrospectively determined.Results This study included 11 patients (6 males). Their mean age was 42.7 years, and eight had leukaemia. Eight were assessed at a mean of 65.4 days post-HSCT. The hip and thigh skeletal muscle FFs were not significantly different during HSCT. The grip and lower limb muscle strengths decreased significantly after HSCT. Patients with low FFs before transplantation tended to lose muscle strength, and the increase in FF and decrease of muscle strength were correlated.Conclusions Muscle strength and quantity decrease during the early phase after HSCT, especially in patients with low FF muscles. Therefore, interventions based on muscle quality and quantity are essential.",
  "authors": [
    {
      "affiliations": [
        "Department of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan"
      ],
      "name": "Yusaku Maeda"
    },
    {
      "affiliations": [
        "Department of Diagnostic Radiology, Tokushima University Graduate School of Health Sciences, Tokushima, Japan"
      ],
      "name": "Shoichiro Takao"
    },
    {
      "affiliations": [
        "Department of Diagnostic Imaging, Shinko Hospital, Kobe, Hyogo, Japan"
      ],
      "name": "Shiori Morita"
    },
    {
      "affiliations": [
        "Division of Rehabilitation, Tokushima University Hospital, Tokushima, Japan"
      ],
      "name": "Shin Kondo"
    },
    {
      "affiliations": [
        "Department of Analytical Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan"
      ],
      "name": "Michiko Yamashita"
    },
    {
      "affiliations": [
        "Department of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan"
      ],
      "name": "Ryohei Sumitani"
    },
    {
      "affiliations": [
        "Department of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan"
      ],
      "name": "Masahiro Oura"
    },
    {
      "affiliations": [
        "Department of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan"
      ],
      "name": "Kimiko Sogabe"
    },
    {
      "affiliations": [
        "Department of Hematology, Kawashima Hospital, Tokushima, Japan"
      ],
      "name": "Mamiko Takahashi"
    },
    {
      "affiliations": [
        "Department of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan"
      ],
      "name": "Shiro Fujii"
    },
    {
      "affiliations": [
        "Department of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan"
      ],
      "name": "Takeshi Harada"
    },
    {
      "affiliations": [
        "Division of Transfusion Medicin and Cell Therapy, Tokushima University Hospital, Tokushima, Japan"
      ],
      "name": "Hirokazu Miki"
    },
    {
      "affiliations": [
        "Department of Hematology, Kawashima Hospital, Tokushima, Japan"
      ],
      "name": "Masahiro Abe"
    },
    {
      "affiliations": [
        "Department of Community Medicine and Medical Science, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan"
      ],
      "name": "Shingen Nakamura"
    }
  ],
  "title": "Quality of skeletal muscles during allogeneic stem-cell transplantation: a pilot study",
  "uid": "7e283d84-27d4-5a55-8de5-22cea16d99db"
}