{
  "abstract": "Introduction Pleural mesothelioma (PM) is often presaged by benign asbestos-associated pleural inflammation (AAPI), offering a unique window of opportunity for translational research. The PREDICT-Meso International Accelerator Network is leveraging this natural history to perform target identification and develop novel therapies for early-stage or pre-invasive disease. This requires assembly of a unique bioresource of longitudinal human tissue samples spanning the terminal stages of PM evolution, development of preclinical models for drug screening and reliable tools for risk prediction in patients presenting with AAPI.Methods and analysis Mesothelioma Observational study of Risk prediction and Generation of paired benign-meso tissue samples, Including a Nested MRI Substudy (Meso-ORIGINS) is a prospective, multicentre observational study, comprising two arms (A and B), with a nested MRI substudy in arm A. Arm A will recruit 300 AAPI patients and perform 6-monthly surveillance for 2 years. Suspicion of PM evolution will prompt repeat biopsy and banking, delivering a primary objective of ≥38 longitudinal AAPI-PM tissue pairs. This target reflects a projected PM evolution rate of 14% (95% CI 10.5 to 19.2) derived from a prior multicentre feasibility trial. Multiomic risk profiling will be performed in arm A, using blood proteomics, exhaled breath metabolomics and perfusion MRI. Arm B will recruit 300 patients with suspected PM, permitting collection of multiregion pleural biopsies in patients spanning AAPI and PM timepoints for evaluation of anatomical heterogeneity. Where possible, patients in arm B diagnosed with AAPI will be recruited to arm A for 2-year surveillance +/− repeat biopsy in subsequent PM evolution cases. Pleural fluid will be collected in arm B for cell-line generation and diagnostic biomarker evaluation. Exhaled breath will be collected in arm B for diagnostic biomarker evaluation.Ethics and dissemination The study has ethical approval (REC Ref 21/WS/0120). Results will be disseminated via peer-reviewed journals and national/international scientific conferences. Tissues, data and derived omics will be shared via the PREDICT-Meso Research Tissue Bank (REC Ref 21/WS/0011).Trial registration number ISRCTN22929761.",
  "authors": [
    {
      "affiliations": [
        "Glasgow Pleural Disease Unit, Queen Elizabeth University Hospital, Glasgow, UK",
        "School of Cancer Sciences, University of Glasgow, Glasgow, UK"
      ],
      "name": "Mark D J Neilly"
    },
    {
      "affiliations": [
        "School of Cancer Sciences, University of Glasgow, Glasgow, UK"
      ],
      "name": "Alexandrea MacPherson"
    },
    {
      "affiliations": [
        "Glasgow Oncology Clinical Trials Unit, Glasgow, UK"
      ],
      "name": "Laura Alexander"
    },
    {
      "affiliations": [
        "Glasgow Oncology Clinical Trials Unit, Glasgow, UK"
      ],
      "name": "Nicola Walker"
    },
    {
      "affiliations": [
        "Glasgow Oncology Clinical Trials Unit, Glasgow, UK"
      ],
      "name": "Caroline Kelly"
    },
    {
      "affiliations": [
        "School of Cancer Sciences, University of Glasgow, Glasgow, UK"
      ],
      "name": "Joshua Roche"
    },
    {
      "affiliations": [
        "Royal Stoke University Hospital, Stoke-on-Trent, UK"
      ],
      "name": "Emad Abugassa"
    },
    {
      "affiliations": [
        "Raigmore Hospital, Inverness, UK"
      ],
      "name": "Liam Allan"
    },
    {
      "affiliations": [
        "Blackpool Teaching Hospital, Blackpool, UK"
      ],
      "name": "Adeel Ashraf"
    },
    {
      "affiliations": [
        "Northumbria Specialist Emergency Care Hospital, Northumbria, UK"
      ],
      "name": "Avinash Aujayeb"
    },
    {
      "affiliations": [
        "University of Bristol Medical School, University of Bristol Academic Respiratory Unit, Bristol, UK",
        "Southmead Hospital, Bristol, UK"
      ],
      "name": "Anna Bibby"
    },
    {
      "affiliations": [
        "Golden Jubilee National Hospital, Clydebank, UK"
      ],
      "name": "Rocco Bilancia"
    },
    {
      "affiliations": [
        "Royal Devon and Exeter Hospital, Exeter, UK"
      ],
      "name": "John Corcoran"
    },
    {
      "affiliations": [
        "Aberdeen Royal Infirmary, Aberdeen, UK"
      ],
      "name": "Mahendran Chetty"
    },
    {
      "affiliations": [
        "University Hospital of North Tees, Stockton-on-Tees, UK"
      ],
      "name": "Kevin Conroy"
    },
    {
      "affiliations": [
        "Wythenshawe Hospital, Manchester, UK"
      ],
      "name": "Christopher Craig"
    },
    {
      "affiliations": [
        "Southmead Hospital, Bristol, UK"
      ],
      "name": "Rebecca Crook"
    },
    {
      "affiliations": [
        "St Thomas’ Hospital, London, UK"
      ],
      "name": "Alveena D’Souza"
    },
    {
      "affiliations": [
        "Derriford Hospital, Plymouth, UK"
      ],
      "name": "Cyrus Daneshvar"
    },
    {
      "affiliations": [
        "Sheffield Teaching Hospitals, Sheffield, UK"
      ],
      "name": "Duneesha DeFoneska"
    },
    {
      "affiliations": [
        "St Thomas’ Hospital, London, UK"
      ],
      "name": "Poppy Denniston"
    },
    {
      "affiliations": [
        "Somerset Lung Centre, Musgrove Park Hospital, Taunton, UK"
      ],
      "name": "Janet Fallon"
    },
    {
      "affiliations": [
        "Ninewells Hospital, Dundee, UK"
      ],
      "name": "Katie Ferguson"
    },
    {
      "affiliations": [
        "Royal Lancaster Infirmary, Morecambe, UK"
      ],
      "name": "Timothy Gatheral"
    },
    {
      "affiliations": [
        "Royal Gwent Hospital, Newport, UK"
      ],
      "name": "Andrew Lloyd Griffiths"
    },
    {
      "affiliations": [
        "Royal Stoke University Hospital, Stoke-on-Trent, UK"
      ],
      "name": "Mohammed Haris"
    },
    {
      "affiliations": [
        "South Tyneside District Hospital, South Tyneside, UK"
      ],
      "name": "Mohammed Hashim"
    },
    {
      "affiliations": [
        "Royal Gwent Hospital, Newport, UK"
      ],
      "name": "Alina Ionescu"
    },
    {
      "affiliations": [
        "St Thomas’ Hospital, London, UK"
      ],
      "name": "Owais Kadwani"
    },
    {
      "affiliations": [
        "Salford Royal Hospital, Salford, UK"
      ],
      "name": "Michelle Macdougall"
    },
    {
      "affiliations": [
        "Glasgow Royal Infirmary, Glasgow, UK"
      ],
      "name": "John D Maclay"
    },
    {
      "affiliations": [
        "Royal Lancaster Infirmary, Morecambe, UK"
      ],
      "name": "Oliver Nesfield Mann"
    },
    {
      "affiliations": [
        "University of Bristol Medical School, University of Bristol Academic Respiratory Unit, Bristol, UK"
      ],
      "name": "Nick Maskell"
    },
    {
      "affiliations": [
        "NHS Lanarkshire University Hospital Monklands, Airdrie, UK"
      ],
      "name": "Morvern Morrison"
    },
    {
      "affiliations": [
        "Glenfield Hospital, University Hospitals of Leicester NHS Trust, Leicester, UK",
        "NIHR Leicester Biomedical Research Centre Respiratory Diseases, Leicester, UK"
      ],
      "name": "Rakesh Panchal"
    },
    {
      "affiliations": [
        "University Hospital of North Tees, Stockton-on-Tees, UK"
      ],
      "name": "Benjamin Prudon"
    },
    {
      "affiliations": [
        "Churchill Hospital, Oxford Respiratory Trials Unit, Oxford, UK",
        "NIHR Oxford Biomedical Research Centre, Oxford, UK"
      ],
      "name": "Najib M Rahman"
    },
    {
      "affiliations": [
        "Glenfield Hospital, University Hospitals of Leicester NHS Trust, Leicester, UK"
      ],
      "name": "Rajini Sudhir"
    },
    {
      "affiliations": [
        "South Tyneside District Hospital, South Tyneside, UK"
      ],
      "name": "Sudarshan Ramsaroop"
    },
    {
      "affiliations": [
        "Kettering General Hospital, Kettering, UK"
      ],
      "name": "Raja Reddy"
    },
    {
      "affiliations": [
        "Western General Hospital, Edinburgh, UK"
      ],
      "name": "Phil Reid"
    },
    {
      "affiliations": [
        "Raigmore Hospital, Inverness, UK"
      ],
      "name": "Elizabeth Sage"
    },
    {
      "affiliations": [
        "Ninewells Hospital, Dundee, UK"
      ],
      "name": "Philip Short"
    },
    {
      "affiliations": [
        "Freeman Hospital, Newcastle upon Tyne, UK"
      ],
      "name": "Andrew E Stanton"
    },
    {
      "affiliations": [
        "Royal Papworth Hospital, Cambridge, UK"
      ],
      "name": "Laura Succony"
    },
    {
      "affiliations": [
        "Kettering General Hospital, Kettering, UK"
      ],
      "name": "Georgios Tsaknis"
    },
    {
      "affiliations": [
        "Glasgow Pleural Disease Unit, Queen Elizabeth University Hospital, Glasgow, UK",
        "Gartnavel General Hospital, Glasgow, UK"
      ],
      "name": "Selina Tsim"
    },
    {
      "affiliations": [
        "Department of Imaging, Queen Elizabeth University Hospital, Glasgow, UK"
      ],
      "name": "Gordon Cowell"
    },
    {
      "affiliations": [
        "Laboratory of Experimental Medicine, University of Antwerp, Antwerpen, Belgium"
      ],
      "name": "Kevin Lamote"
    },
    {
      "affiliations": [
        "Glasgow Pleural Disease Unit, Queen Elizabeth University Hospital, Glasgow, UK",
        "School of Cancer Sciences, University of Glasgow, Glasgow, UK"
      ],
      "name": "Kevin G Blyth"
    }
  ],
  "title": "Protocol for Mesothelioma Observational study of Risk prediction and Generation of paired benign-meso tissue samples, Including a Nested MRI Substudy (Meso-ORIGINS)",
  "uid": "991462fd-00cb-55d1-8f06-c38e563ec974"
}