{
  "abstract": "Introduction Disruption to services due to the COVID-19 pandemic has led to an increased demand for pulmonary function testing (PFT). Healthcare systems, including the NHS, have responded by prioritising respiratory medicine; expanding diagnostic capacity through increasing activity and opening community diagnostic centres. As services scale and operate multiple PFT systems concurrently, healthcare professionals require confidence that patient results are consistent across devices. Assessment of inter- and intra-device variability is essential to support reliable clinical interpretation and longitudinal testing.Aims The aim of this study was to assess inter- and intra-device variability for PFT measurements obtained using VitaloLAB PFT systems. We hypothesized that repeated measurements would show low variability both within and between devices, such that device-related effects would be low relative to expected biological variation.Methods 19 healthy participants,18-65 years, completed 3 PFT sessions on separate days using 2 VitaloLAB PFT systems (VitaloLAB A and VitaloLAB B). Participants were randomised to perform two sessions on one device and one session on the other (e.g. AAB or BBA). Each session included spirometry, diffusing capacity (DLCO) and lung volumes (multiple breath nitrogen washout, MBN2) tests. Tests were conducted by trained respiratory physiologists in accordance with ERS/ATS technical standards. Inter- and intra-device variability was assessed using Bland-Altman analysis.Results Datasets were obtained for all 19 participants across all tests. Preliminary analyses indicate low within-subject variability across repeated test sessions on the same device and small absolute differences between devices across all test types. Observed variability was consistent with expected variation, accounting for biological and within test variation. The bias across both systems for FEV1 was 0.03 (SD 0.26), FVC was -0.04 (SD 0.19), TLCO was 0.39 (SD 0.82), KCO was 0.17 (SD 0.06), FRC was 0.15 (SD 0.41) and TLC was 0.23 (SD 0.48).Conclusions In healthy individuals, inter- and intra- device variability for key PFT parameters met ERS/ATS guidelines when testing was performed on identical VitaloLab PFT systems. These findings support the comparability of results when multiple VitaloLAB systems of the same type are used within a clinical service, offering confidence in the consistency of patient results across devices.",
  "authors": [
    {
      "affiliations": [
        "Vitalograph UK, Buckingham, United Kingdom"
      ],
      "name": "Claire Cherry"
    },
    {
      "affiliations": [
        "Vitalograph UK, Buckingham, United Kingdom"
      ],
      "name": "Tasmin Johnson"
    },
    {
      "affiliations": [
        "Vitalograph UK, Buckingham, United Kingdom"
      ],
      "name": "Lisa Fazackerley"
    },
    {
      "affiliations": [
        "Vitalograph UK, Buckingham, United Kingdom"
      ],
      "name": "Joe Topham"
    },
    {
      "affiliations": [
        "Vitalograph UK, Buckingham, United Kingdom"
      ],
      "name": "Adrian Kendrick"
    }
  ],
  "title": "P63 Inter- and intra- device variability of pulmonary function testing across VitaloLAB systems",
  "uid": "7cda8feb-91aa-523b-9c46-4c51c9ee6530"
}