{
  "abstract": "Background Bronchoscopic thermal vapour ablation (BTVA) is a treatment option for selected patients with severe emphysema, inducing lung volume reduction through a localised inflammatory response. This study investigated sex-specific differences in outcomes and safety after BTVA.Methods Data from the multicentre BTVA post-market registry (December 2018–July 2024) were retrospectively analysed. Sex-specific outcomes at 3, 6 and 12 months were compared, and the effect of sex on residual volume (RV%) was assessed using an adjusted mixed-effects model.Results A total of 231 patients (105 women) were included. In women, significant improvements were observed in forced expiratory volume in 1 s at 3, 6 and 12 months (+60 mL, +70 mL, +20 mL), RV at 6 and 12 months (–0.38 L and –0.50 L), 6-Minute Walk Distance (6-MWD) at 3 and 6 months (+17.5 m and +23.5 m), and a consistent improvement in St. George’s Respiratory Questionnaire (SGRQ) at 3, 6 and 12 months (–9.3, –6.9, –9.1). In men, significant improvements were noted in RV at 3, 6 and 12 months (–0.32 L, –0.47 L, –0.32 L) and in SGRQ at 3 and 6 months (–4.8 and –3.7), but not at 12 months. An improvement in 6-MWD was not observed in men. Additionally, a significant time-by-sex interaction was observed for RV% (χ²=5.88, p=0.015), indicating distinct RV trajectories between the sexes.Conclusions The results indicate that women experienced greater improvements in lung function and SGRQ scores after BTVA, which may be explained by differences in perception and reporting of functional benefits, as well as potential biological factors such as a stronger inflammatory response.",
  "authors": [
    {
      "affiliations": [
        "Department of Pneumology and Critical Care Medicine, Thoraxklinik, Heidelberg, Germany",
        "Department of Pneumology and Critical Care Medicine, Heidelberg University, Thoraxklinik, Heidelberg, Germany"
      ],
      "name": "Franziska C Trudzinski"
    },
    {
      "affiliations": [
        "Thoraxklinik at University of Heidelberg, Heidelberg, Germany"
      ],
      "name": "Konstantina Kontogianni"
    },
    {
      "affiliations": [
        "Klinik Floridsdorf, Karl Landsteiner Institute for Lung Research and Pulmonary Oncology, Vienna, Austria"
      ],
      "name": "Arschang Valipour"
    },
    {
      "affiliations": [
        "Department of Respiratory and Critical Care Medicine, Karl Landsteiner Institute for Lung Research and Pulmonary Oncology, Vienna, Austria"
      ],
      "name": "Theresa Klemm"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, Martin-Luther University, Halle an der Saale, Germany"
      ],
      "name": "Stephan Eisenmann"
    },
    {
      "affiliations": [
        "Department of Respiratory Medicine, Allergology and Sleep Medicine, Klinikum Nuernberg/Paracelsus Medical University, Nuremberg, Germany",
        "Klinikum Nürnberg/PMU, Nürnberg, Germany"
      ],
      "name": "Joachim Ficker"
    },
    {
      "affiliations": [
        "Department of Medicine and Pulmonology, Hospital Uster, Uster, Switzerland",
        "Department of Respiratory Medicine, UniversitätsSpital Zürich, Zürich, Switzerland"
      ],
      "name": "Daniel Franzen"
    },
    {
      "affiliations": [
        "Klinik für Pneumologie, Asklepios Fachkliniken Munchen-Gauting, Gauting, Germany"
      ],
      "name": "Wolfgang Gesierich"
    },
    {
      "affiliations": [
        "Department of Internal Medicine and Respiratory Medicine, Gemeinschaftskrankenhaus Havelhöhe gGmbH, Berlin, Germany"
      ],
      "name": "Christian Grah"
    },
    {
      "affiliations": [
        "Department of Pneumology and Critical Care Medicine, Heidelberg University, Thoraxklinik, Heidelberg, Germany",
        "Department of Pneumology and Critical Care Medicine, Thoraxklinik-Heidelberg gGmbH, Heidelberg, Germany"
      ],
      "name": "Susanne Dittrich"
    },
    {
      "affiliations": [
        "Pneumology, Thoraxklinik-Heidelberg gGmbH, Heidelberg, Germany"
      ],
      "name": "Philipp Höger"
    },
    {
      "affiliations": [
        "Lungenfachklinik Immenhausen, Immenhausen, Germany"
      ],
      "name": "Peter Hammerl"
    },
    {
      "affiliations": [
        "Klinik für Pneumologie, Internistische Intensivmedizin, Krankenhaus vom Roten Kreuz, Stuttgart, Germany"
      ],
      "name": "Martin Hetzel"
    },
    {
      "affiliations": [
        "Institute of Medical Biometry, University of Heidelberg, Heidelerg, Germany"
      ],
      "name": "Teresa Byczkowski"
    },
    {
      "affiliations": [
        "Institute of Medical Biometry, University of Heidelberg, Heidelerg, Germany"
      ],
      "name": "Manuel Feisst"
    },
    {
      "affiliations": [
        "Department of Pneumology and Critical Care Medicine, Thoraxklinik am Universitätsklinikum Heidelberg, Heidelberg, Germany"
      ],
      "name": "Felix Herth"
    },
    {
      "affiliations": [
        "Department of Pulmonary Medicine, Lungenklinik Hemer, Hemer, Germany"
      ],
      "name": "Kaid Darwiche"
    }
  ],
  "title": "Sex differences in efficacy and adverse events following bronchoscopic thermal vapour ablation for severe emphysema: results from a multinational real-world registry",
  "uid": "54dc0824-81d8-5352-8f68-dcb38edbd4ee"
}