{
  "abstract": "Background Bronchiectasis is a respiratory disease structurally characterised by irreversible airway dilatation. Functional impairments are also implicated in bronchiectasis, but the detailed changes in pulmonary function and the impact of clinical factors are yet to be examined. We analysed pulmonary function in patients with bronchiectasis based on their clinical features.Methods Two study cohorts—a multicentre bronchiectasis registry and health check-up examinees—were analysed. Airflow limitation was defined as forced expiratory volume in 1 s (FEV 1)/forced vital capacity (FVC) <0.7, and bronchiectasis severity was categorised using the number of involved lobes.Results Among 13 589 health check-up examinees, 606 (4.5%) had bronchiectasis; airflow limitation was more prevalent in those with bronchiectasis than in those without (17.3% vs 8.1%, p<0.001). Ever-smokers with bronchiectasis had the lowest FEV 1, FEV1/FVC and FVC values, and the highest prevalence of airflow limitation. In the bronchiectasis registry (n=768), lung function parameters were worse in those with more involved lobes and Pseudomonas colonisation. Multivariable logistic regression analysis showed that bronchiectasis was independently associated with airflow limitation (OR 2.22 (95% CI 1.75 to 2.82)).Conclusions Bronchiectasis is an independent risk factor for airflow limitation, and disease severity, smoking and Pseudomonas colonisation were each associated with worsening in pulmonary function.",
  "authors": [
    {
      "affiliations": [
        "Department of Pulmonology and Critical Care Medicine, Hanyang University Guri Hospital, Guri, Korea (the Republic of)"
      ],
      "name": "Da Som Jeon"
    },
    {
      "affiliations": [
        "Department of Health Promotion Center, University of Ulsan College of Medicine, Songpa-gu, Korea (the Republic of)",
        "Department of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea (the Republic of)"
      ],
      "name": "Young Ju Jung"
    },
    {
      "affiliations": [
        "Department of Pulmonology and Critical Care Medicine, Pusan National University Hospital, Busan, Korea (the Republic of)"
      ],
      "name": "Soo Han Kim"
    },
    {
      "affiliations": [
        "Department of Pulmonology and Critical Care Medicine, Chungbuk National University College of Medicine, Cheongju, Korea (the Republic of)"
      ],
      "name": "Bumhee Yang"
    },
    {
      "affiliations": [
        "Department of Pulmonology and Critical Care Medicine, Seoul National University Bundang Hospital, Seongnam, Korea (the Republic of)"
      ],
      "name": "Byoung Soo Kwon"
    },
    {
      "affiliations": [
        "Department of Pulmonology and Critical Care Medicine, Eunpyeong St.Mary's Hospital, The Catholic University of Korea, Seoul, Korea (the Republic of)"
      ],
      "name": "Sang Haak Lee"
    },
    {
      "affiliations": [
        "Department of Pulmonology and Critical Care Medicine, Inje University Busan Paik Hospital, Busan, Korea (the Republic of)"
      ],
      "name": "Hyun-Kyung Lee"
    },
    {
      "affiliations": [
        "Department of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea (the Republic of)"
      ],
      "name": "Jae Seung Lee"
    },
    {
      "affiliations": [
        "Department of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea (the Republic of)"
      ],
      "name": "Yeon-Mok Oh"
    },
    {
      "affiliations": [
        "Department of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea (the Republic of)"
      ],
      "name": "Sei Won Lee"
    }
  ],
  "title": "Pulmonary function and airflow limitation in bronchiectasis: a case-control study of two independent cohorts",
  "uid": "6d4a1c2f-6b07-59d8-86a4-5cf824fc3863"
}