{
  "abstract": "Introduction Yoga is an emerging exercise choice for people with cystic fibrosis (CF), but evidence of its effect in this population is scarce, with a recent systematic review advocating for further research. Yoga Outcomes Get Assessed in CF (YOGA-CF) is a real-world multicentre randomised controlled trial (RCT) investigating a bespoke CF-specific online 12-week yoga intervention, vers usual care, to determine effectiveness for adults with CF.Methods and analysis A multicentre RCT of adults with CF across the UK. Participants are randomised to usual care or a 12-week online bespoke yoga programme with an expectation of two classes completed weekly. Assessments of lung function, 1 min sit-to-stand, the Cystic Fibrosis Questionnaire-Revised (CFQ-R) and other trial questionnaires are completed preintervention and postintervention (0 and 12 weeks) and after 12 weeks of follow-up (week 24). The primary outcome is the difference in respiratory-related quality of life measured using the CFQ-R before and after yoga/control. Sample size was calculated based on detecting a minimally clinically important difference of 4 for the CFQ-R respiratory domain, with power of 80% and 5% significance level (total target, n=314).Ethics and dissemination Ethics approval gained from the South Yorkshire and Humber Research Ethics Committee (REC) (reference: 23/YH/0270, project ID 303898). Dissemination to involve direct participant feedback and lay webinar, scientific conference presentation and publication in a peer-reviewed journal.Trial registration number NCT06120465.",
  "authors": [
    {
      "affiliations": [
        "Department of Adult Cystic Fibrosis, Royal Brompton Hospital, Guy's and St Thomas’ Hospitals NHS Trust, London, England, UK",
        "National Heart and Lung Institute, Imperial College London, London, UK"
      ],
      "name": "Gemma E Stanford"
    },
    {
      "affiliations": [
        "Independent Yoga & Cystic Fibrosis Expert, Sydney, New South Wales, Australia"
      ],
      "name": "P Scarborough"
    },
    {
      "affiliations": [
        "Cystic Fibrosis Trust, London, UK"
      ],
      "name": "Susan C Charman"
    },
    {
      "affiliations": [
        "Norwich Medical School, University of East Anglia, Norwich, England, UK",
        "NIHR Applied Research Collaboration East of England, Cambridge, UK"
      ],
      "name": "Rory A Cameron"
    },
    {
      "affiliations": [
        "Norwich Medical School, University of East Anglia, Norwich, England, UK",
        "NIHR Applied Research Collaboration East of England, Cambridge, UK"
      ],
      "name": "Adam P Wagner"
    },
    {
      "affiliations": [
        "Department of Adult Cystic Fibrosis, Royal Brompton Hospital, Guy's and St Thomas’ Hospitals NHS Trust, London, England, UK",
        "National Heart and Lung Institute, Imperial College London, London, UK"
      ],
      "name": "Nicholas J Simmonds"
    }
  ],
  "title": "Yoga Outcomes Get Assessed in Cystic Fibrosis (YOGA-CF): protocol of a multicentre interventional randomised controlled clinical trial—investigating effects of a 12-week yoga intervention for adults with cystic fibrosis",
  "uid": "c9fb3270-e3b3-58bf-a978-a9efee3897f3"
}