{
  "abstract": "Objectives Paediatric acute respiratory distress syndrome (PARDS) is a heterogeneous condition and identifying a specific biomarker remains a challenge. We aimed to validate the association of plasma soluble receptor for advanced glycation end-products (sRAGE) and angiopoietin-2 (Ang-2) with PARDS diagnosis, and its prognostic performance.Methods This prospective observational study included children with PARDS and non-PARDS critical illness. Plasma sRAGE and Ang-2 levels were measured using enzyme-linked immunosorbent assays. Comparisons were made between PARDS versus non-PARDS critical illness and survivors versus non-survivors. Multivariable logistic regression was used to determine the association between biomarkers and intensive care unit (ICU) mortality after adjusting for age and the Pediatric Index of Mortality 3 score.Results 93 and 117 patients with PARDS and non-PARDS critical illness, respectively, were included in this study. Plasma sRAGE was higher in PARDS versus non-PARDS critical illness (2981 (1027 to 6198) vs 1575 (864 to 2994) pg/mL; p=0.002) and in non-survivors vs survivors (5323 (1647 to 8261) vs 1601 (864 to 3572); p<0.001). Plasma Ang-2 was elevated in non-survivors versus survivors (3054 (1760 to 6808) vs 1748 (845 to 3868); p=0.002), though there was no difference between PARDS and non-PARDS groups. In the multivariable model, sRAGE demonstrated an independent association with PARDS diagnosis (adjusted OR (aOR) 1.01 95% CI 1.01 to 1.02; p=0.003) and ICU mortality (aOR 1.02 (95% CI 1.01 to 1.03); p<0.001), whereas there was no association observed with Ang-2.Conclusion Within an ICU cohort, only sRAGE demonstrated an association with the diagnosis of PARDS and ICU mortality, which remained after controlling for confounders.",
  "authors": [
    {
      "affiliations": [
        "Children’s Intensive Care Unit, KK Women's and Children’s Hospital, Singapore",
        "Duke-NUS Medical School, Singapore"
      ],
      "name": "Judith Ju Ming Wong"
    },
    {
      "affiliations": [
        "Respiratory Therapy Service, Division of Allied Health Specialties, KK Women’s and Children’s Hospital, Singapore"
      ],
      "name": "Herng Lee Tan"
    },
    {
      "affiliations": [
        "Children’s Intensive Care Unit, KK Women's and Children’s Hospital, Singapore"
      ],
      "name": "Clare Foo"
    },
    {
      "affiliations": [
        "Duke-NUS Medical School Centre for Quantitative Medicine, Singapore"
      ],
      "name": "Rehana Sultana"
    },
    {
      "affiliations": [
        "Children’s Intensive Care Unit, KK Women's and Children’s Hospital, Singapore",
        "Duke-NUS Medical School, Singapore"
      ],
      "name": "Yee Hui Mok"
    },
    {
      "affiliations": [
        "SingHealth Duke-NUS Translational Immunology Institute, Singapore",
        "Division of Medicine, KK Women's and Children’s Hospital, Singapore"
      ],
      "name": "Salvatore Albani"
    },
    {
      "affiliations": [
        "SingHealth Duke-NUS Translational Immunology Institute, Singapore",
        "Division of Medicine, KK Women's and Children’s Hospital, Singapore"
      ],
      "name": "Joo Guan Yeo"
    }
  ],
  "title": "Validation of plasma soluble receptor of advanced glycation end-products and angiopoietin-2 in paediatric acute respiratory distress syndrome",
  "uid": "06cd0690-7004-5b75-a9d9-a37c54ad9504"
}