{
  "abstract": "Background Silicosis, caused by inhaling crystalline silica, is a growing global health concern exacerbated by the increased use of artificial stone. In end-stage silicosis, lung transplantation may be the only available treatment. While double lung transplantation has long-term survival benefits over single lung transplantation, this issue was not assessed in patients with silicosis.Research question Our study aimed to evaluate survival outcomes in silicosis patients undergoing lung transplantation, comparing single versus double lung transplants.Study design and methods This is a single-centre retrospective cohort study of all patients who underwent lung transplantation for silicosis at our centre between March 2006 and March 2024.Results During the study period, our centre conducted 778 lung transplantations, 40 of them (5.14%) were for silicosis, 25 single lung transplants and 15 double lung transplants. Double lung transplantation recipients experienced a more challenging surgical course due to adhesions and difficulty in explantation, associated with a significantly higher volume of blood products (8.00±15.13 units vs 24.85±24.41 units, p=0.023) and longer ischaemic times (243.63±85.36 min vs 327.67±95.23 min, p=0.009). There was no significant difference in the risk of death or re-transplantation in the single lung versus the double lung group (HR 1.163, 95% CI 0.473 to 2.861; p=0.74). Additionally, the two groups had no significant disparities in pulmonary function test results at 1 and 3 years post-transplant (51.93±22.43 vs 66.67±32.09 forced expiratory volume in the first second percent predicted at 36 months follow-up, p=0.25).Conclusion Given the intricate surgical procedure required for transplanting lungs in cases of silicosis, longer ischaemic times, increased need for blood products and the absence of definitive evidence supporting double lung transplantation in this population, it may be prudent to contemplate prioritising single lung transplantation for these patients.",
  "authors": [
    {
      "affiliations": [
        "Pulmonary Institute, Schneider Children’s Medical Center of Israel, Petah Tikva, Israel",
        "School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel"
      ],
      "name": "Miri Dotan"
    },
    {
      "affiliations": [
        "School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel",
        "Pulmonary Institute, Rabin Medical Center, Petah Tikva, Israel"
      ],
      "name": "Dror Rosengarten"
    },
    {
      "affiliations": [
        "School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel",
        "Department of Anesthesiology, Rabin Medical Center, Petah Tikva, Israel"
      ],
      "name": "Karam Azem"
    },
    {
      "affiliations": [
        "School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel",
        "Department of Anesthesiology, Rabin Medical Center, Petah Tikva, Israel"
      ],
      "name": "Shai Fein"
    },
    {
      "affiliations": [
        "School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel",
        "Pulmonary Institute, Rabin Medical Center, Petah Tikva, Israel"
      ],
      "name": "Yael Shostak"
    },
    {
      "affiliations": [
        "School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel",
        "Pulmonary Institute, Rabin Medical Center, Petah Tikva, Israel"
      ],
      "name": "Dorit Shitenberg"
    },
    {
      "affiliations": [
        "School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel",
        "Department of Thoracic Surgery, Rabin Medical Center, Petah Tikva, Israel"
      ],
      "name": "Yuri Peysakhovich"
    },
    {
      "affiliations": [
        "School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel",
        "Department of Thoracic Surgery, Rabin Medical Center, Petah Tikva, Israel"
      ],
      "name": "Yaron D Barac"
    },
    {
      "affiliations": [
        "School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel",
        "Institute of Pulmonary and Allergic Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"
      ],
      "name": "Elizabeth Fireman"
    },
    {
      "affiliations": [
        "Medicine, University of Califronia San Francisco, San Francisco, California, USA"
      ],
      "name": "Paul Blanc"
    },
    {
      "affiliations": [
        "School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel",
        "Pulmonary Institute, Rabin Medical Center, Petah Tikva, Israel"
      ],
      "name": "Osnat Shtraichman"
    },
    {
      "affiliations": [
        "School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel",
        "Pulmonary Institute, Rabin Medical Center, Petah Tikva, Israel"
      ],
      "name": "Mordechai Reuven Kramer"
    }
  ],
  "title": "Single versus double lung transplantation outcomes in artificial stone silicosis: a single-centre retrospective cohort study",
  "uid": "b1e02367-1573-55a6-aea8-e244e49b4cde"
}