{
  "abstract": "Background Chronic Obstructive Pulmonary Disease (COPD) is a condition characterised by lung inflammation, and lung tissue damage which causes airway obstruction making it challenging to breathe (Pauwels et al., 2001). Symptoms such as an increased sensation of breathlessness and reduced exercise capacity can be caused by a decreased elasticity of the lungs, and early airway closure causes gas trapping within the lungs (Sindh et al., 2019). The primary method of assessing gas trapping is body plethysmography, however some patients struggle in performing elements of the test, making the results inaccurate.Aim The aim of this research is to highlight the utilisation of new technology, identifying if using the forced oscillation technique to determine closing volume (CVFOT) can be used as an assessment of gas trapping.Methods Ethical approval was obtained from the Health Research Authority. Participants included 15 patients (5 female, 10 male; age 66.7 ± 9.5 years, height 170.7 ± 11.3 cm and weight 76.8 ± 14.5 kg) with a known diagnosis of COPD. On the day of examination, measurements of respiratory impedance and closing volume using FOT (Resmon Pro Full Restech, Milano-Italy) at 5, 11 and 19 Hz and static lung volumes by body plethysmography (Jaeger Master-screen, Vyaire Medical, Germany) were performed. Results analysed utilising Pearson’s correlation (v1.2.0; R Studio, 2023) to determine the relationship between measurements.Results When examining the relationship between CVFOT [%Vital Capacity (VC) predicted] and residual volume (RV) measured by body plethysmography Standard Residual (SR), analysis identified a strong positive (R = 0.735) and significant (P-Value = 0.001) correlation. ( Figure 1)Abstract P10 Figure 1Comparison of RV performed as part of body plethysmography and CVFOT from 15 patients with confirmed diagnosis of COPD. Graph A shows the relationship between RV [Standard Residual] and CVFOT [%VCpred]. Graph B shows this relationship when normalised to the patients total lung capacity using RV/TLC [Standard Residual]Conclusion The results of this study highlights the potential utility of CVFOT in determining the presence of gas trapping in comparison to results from body plethysmography. Additional research to better identify the specificity and sensitivity of these tests against already established markers of pathophysiology in a larger cohort is warranted including the examination of results in other pathologies which cause obstructive lung disease.",
  "authors": [
    {
      "affiliations": [
        "Respiratory Physiology, Cambridge University Hospitals, Cambridge, UK"
      ],
      "name": "Ella O’Neill"
    },
    {
      "affiliations": [
        "Respiratory Physiology, Royal Papworth Hospital, Cambridge, UK"
      ],
      "name": "Karl Peter Sylvester"
    },
    {
      "affiliations": [
        "Respiratory Medicine, Cambridge University Hospitals, Cambridge, UK"
      ],
      "name": "Jonathan Fuld"
    }
  ],
  "title": "P10 Does closing volume measured by forced oscillation technique reflect airway closure and gas trapping in comparison to whole body plethysmography?",
  "uid": "20379114-d39c-5362-887d-cd366facb8c4"
}