{
  "abstract": "Objective To evaluate the analgesic efficacy and physiological effects of oral sucrose during lumbar puncture (LP) in term neonates.Study design This double-blind, randomised trial enrolled 60 full-term neonates undergoing LP. Participants were randomly given 2 mL of 25% oral sucrose or sterile water 2 min before the procedure. The primary outcome was pain score change from baseline via the Neonatal Infant Pain Scale (NIPS). Secondary outcomes included changes in heart rate (HR), respiratory rate (RR), and oxygen saturation (SpO₂). Measurements were taken at baseline, 1 min, and 3 min post-LP.Results The sucrose group showed significantly smaller changes in NIPS scores at 1 min (1.0 vs 5.0, p<0.001) and 3 min (0.0 vs 4.0, p<0.001), along with smaller HR increases (p=0.012) and SpO₂ decreases (p=0.023) at 1 min post-procedure. Clinically significant tachycardia (HR >160 bpm) occurred in 40% of controls vs 13.3% of sucrose-treated infants (p=0.045), and desaturation (SpO₂ <90%) in 26.7% of controls vs 6.7% of the sucrose group (p=0.038).Conclusion A 2 mL dose of 25% oral sucrose administered 2 min prior to LP is a safe and effective intervention that significantly reduces behavioural and physiological markers of pain in term neonates during the immediate post-procedural period.",
  "authors": [
    {
      "affiliations": [
        "Pediatrics & Neonatology, Alborz University of Medical Sciences, Karaj, Alborz Province, Iran (the Islamic Republic of)"
      ],
      "name": "Alireza Jashni Motlagh"
    },
    {
      "affiliations": [
        "Alborz University of Medical Sciences, Karaj, Alborz Province, Iran (the Islamic Republic of)"
      ],
      "name": "Sina Mashayekhipour"
    },
    {
      "affiliations": [
        "Reproductive Health, Alborz University of Medical Sciences, Karaj, Alborz Province, Iran (the Islamic Republic of)"
      ],
      "name": "Mahsa Khoshnam Rad"
    },
    {
      "affiliations": [
        "Thoracic Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Tehran Province, Iran (the Islamic Republic of)"
      ],
      "name": "Niloofar Khoshnam Rad"
    }
  ],
  "title": "The efficacy of oral sucrose for relieving lumbar puncture pain in neonates: a randomised clinical trial",
  "uid": "ca623539-215d-5ca4-aa91-d3839b344738"
}