{
  "abstract": "Objectives Maternal diabetes is linked to adverse perinatal outcomes, but its association with neurodevelopmental delays in offspring remains unclear. This study aimed to investigate the relationship between maternal diabetes and neurodevelopmental outcomes in children born to Qatari mothers.Methods This retrospective population-based cohort study included full-term children born in 2017 to Qatari mothers with gestational diabetes, pre-pregnancy diabetes, or no diabetes. Neurodevelopmental outcomes such as autism spectrum disorder (ASD), speech delay, and gross and fine motor delays were assessed at the age of 4 years. Data for the study were retrieved from electronic medical records.Results Of the 5141 eligible children, 1222 (23.8%) were born to mothers with gestational diabetes mellitus (GDM), 140 (2.7%) to mothers with pre-pregnancy diabetes and 3779 (73.5%) to non-diabetic mothers. Overall, 70 (1.58%) children were diagnosed with autism, 161 (3.63%) with speech delay, 44 (0.99%) with gross motor delay and 43 (0.97%) with fine motor delay. In crude analyses, children of mothers with GDM had significantly higher odds of autism (OR 1.70, 95% CI 1.03 to 2.81) and speech delay (OR 1.44, 95% CI 1.02 to 2.04) compared with controls. However, these associations were not statistically significant after adjusting for confounders (autism: adjusted odds ratio (aOR) 1.58, 95% CI 0.94 to 2.66; speech delay: adjusted odds ratio (aOR) 1.39, 95% CI 0.97 to 2.00). No significant associations were observed between maternal diabetes and gross or fine motor delays in either crude or adjusted models.Conclusion Despite non-significant associations, findings highlight the role of effective diabetes management and the need for region-specific, longitudinal research on child neurodevelopment.",
  "authors": [
    {
      "affiliations": [
        "Department of Developmental Pediatrics, Hamad Medical Corporation, Doha, Qatar"
      ],
      "name": "Razan M Masri"
    },
    {
      "affiliations": [
        "Neonatal Intensive Care Unit (NICU), Women’s Wellness and Research Center (WWRC), Hamad Medical Corporation, Doha, Qatar"
      ],
      "name": "Mohammad A A Bayoumi"
    },
    {
      "affiliations": [
        "Department of Medical Education, Sidra Medicine, Doha, Qatar"
      ],
      "name": "Rasha I Amin"
    },
    {
      "affiliations": [
        "Department of Medical Education, Sidra Medicine, Doha, Qatar",
        "Department of Medical Education, Hamad Medical Corporation, Doha, Qatar",
        "Division of Critical Care Medicine, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada"
      ],
      "name": "Hafsa O A Alsharif"
    },
    {
      "affiliations": [
        "Department of Medical Education, Hamad Medical Corporation, Doha, Qatar"
      ],
      "name": "Amna Musa"
    },
    {
      "affiliations": [
        "West Bay Medicare (WBM), Doha, Qatar"
      ],
      "name": "Ahmad S Mudrek"
    },
    {
      "affiliations": [
        "Department of Medical Education, Hamad Medical Corporation, Doha, Qatar"
      ],
      "name": "Basma A M R Selim"
    },
    {
      "affiliations": [
        "Medical Research Center, Hamad Medical Corporation, Doha, Qatar"
      ],
      "name": "Prem Chandra"
    },
    {
      "affiliations": [
        "Department of Public Health, Qatar University College of Health Sciences, Doha, Qatar"
      ],
      "name": "Samah Elshaar"
    }
  ],
  "title": "Neurodevelopmental outcomes of children born to diabetic mothers in the Qatari population: a retrospective study",
  "uid": "558059e2-be52-53e9-bfc5-b03271afb2a8"
}