{
  "abstract": "Background Eosinophilic esophagitis (EoE) is an immune-mediated disease characterised by oesophageal eosinophilic infiltration, leading to chronic inflammation and tissue remodelling.Objectives To describe the clinical, epidemiological and endoscopic characteristics of children with EoE in Colombia, and explore associations between symptoms, allergen sensitisation and endoscopic findings.Methods Observational, multicentre retrospective study with an analytical component, conducted on paediatric patients diagnosed with EoE across 10 tertiary referral centres in Colombia between 2015 and 2023. All cases had histological confirmation with ≥15 eosinophils per high-power field. Data were extracted from standardised medical records by trained investigators.Results A total of 143 cases were included, with a male predominance (66.4%) and median age at diagnosis of 92 months (IQR 56–144). Relevant early exposures included prematurity (11.2%), low birth weight (10.5%), caesarean delivery (50.3%), infant formula use (62.2%) and antibiotics in infancy (27.9%). Family history of atopy was present in 54.6%, and EoE in 4.9%. Food specific IgE was present, particularly to cow’s milk (56.6%) and egg (38.1%). Most frequent symptoms included abdominal pain (67.1%), nausea (60.1%) and vomiting (46.2%). Endoscopic findings included longitudinal furrows (70.9%) and white exudates (67.4%). Statistically significant associations were found between dysphagia and oesophageal rings (p=0.003), vomiting and white exudates (p=0.018), abdominal pain and longitudinal furrows (p=0.025) and regurgitation and oedema (p=0.031).Conclusions Paediatric EoE in Colombia shows symptom and endoscopic heterogeneity. Identifying potential allergen triggers may contribute to understanding symptoms and endoscopic patterns in EoE.",
  "authors": [
    {
      "affiliations": [
        "Pediatrics Gastroenterologist, Universidad Nacional de colombia, Facultad de Medicina, Departamento de pediatria (UNAL), Universidad el Bosque, Hospital Infantil Universitario de San José (HIUSJ), Bogotá, Colombia"
      ],
      "name": "Michelle Higuera Carrillo"
    },
    {
      "affiliations": [
        "Pediatrics Gastroenterologist, Universidad de Los Andes, Fundacion Santa Fe de Bogota, Bogotá, Colombia"
      ],
      "name": "Ailim Margarita Carias Domínguez"
    },
    {
      "affiliations": [
        "Pediatrics Gastroenterologist, Universidad de Pamplona, Hospital Universitario Erasmo Meoz, Cucuta, Norte de Santander, Colombia"
      ],
      "name": "Natali Gonzalez Rozo"
    },
    {
      "affiliations": [
        "Pediatrics Gastroenterologist, Head of the Gastroenterology, Hepatology and Pediatric Nutritional Support Group Section, Fundación Santa Fe de Bogotá, Facultad de Medicina, Universidad de los Andes, Bogotá, Colombia"
      ],
      "name": "José Fernando Vera Chamorro"
    },
    {
      "affiliations": [
        "Pediatrics Gastroenterologist, Colegio Colombiano de Gastroenterología, Hepatología y Nutrición Pediátrica (COLGAHNP), Scientific Director, General Manager, JPR Gastroenterology Unit, Bogotá, Colombia"
      ],
      "name": "Juan Pablo Riveros López"
    },
    {
      "affiliations": [
        "Pediatrics Gastroenterologist, Hospital Pablo Tobon Uribe, Medellín, Antioquia, Colombia"
      ],
      "name": "Catalina Ortiz-Piedrahita"
    },
    {
      "affiliations": [
        "Pediatrics Gastroenterologist, Hospital Internacional de Colombia, Fundacion Cardiovascular de Colombia, Floridablanca, Santander, Colombia"
      ],
      "name": "Carlos Augusto Cuadros Mendoza"
    },
    {
      "affiliations": [
        "Pediatrics Gastroenterologist, Master’s Candidate in Epidemiology, Fundación LaCardio, Fundacion HOMI Hospital de la Misericordia, Bogotá, Colombia"
      ],
      "name": "Stephania Peña Hernández"
    },
    {
      "affiliations": [
        "Pediatric Allergy and Immunology Specialist, Fundación Hospital pediátrico la Misericordia - HOMI, Bogotá, Colombia"
      ],
      "name": "Natalia Velez-Tirado"
    },
    {
      "affiliations": [
        "Pediatrics Gastroenterologist, Pedigastric IPS, Villavicencio, Meta, Colombia"
      ],
      "name": "César Augusto Moreno Serrano"
    },
    {
      "affiliations": [
        "Clínica Imbanaco Grupo Quirón-Salud, Pontificia Universidad Javeriana, Cali, Colombia"
      ],
      "name": "Otto Gerardo Calderón-Guerrero"
    },
    {
      "affiliations": [
        "Pediatrics Gastroenterologist, Centro Médico UGANEP, Asociación Colombiana de Probióticos y Prebióticos, Bucaramanga, Santander, Colombia"
      ],
      "name": "Fernando Alonso Medina Monroy"
    },
    {
      "affiliations": [
        "Pediatrics Gastroenterologist, Clinica del Country, Bogotá, Colombia"
      ],
      "name": "Adriana Prada Rey"
    },
    {
      "affiliations": [
        "Pediatrics Deparment, Universidad El Bosque, Bogotá, Colombia"
      ],
      "name": "Juanita Higuera"
    },
    {
      "affiliations": [
        "Pediatrics Gastroenterologist, Hospital Pablo Tobon Uribe, Medellín, Antioquia, Colombia"
      ],
      "name": "Monica Maria Contreras Ramirez"
    },
    {
      "affiliations": [
        "Research and Development Department, Miramar MedCom, Miramar, Mexico"
      ],
      "name": "Carlos Marcelo Timossi"
    },
    {
      "affiliations": [
        "Pediatrics Deparment, Sociedad de Cirugía de Bogotá - Hospital de San José",
        "Pediatrics Deparment, Fundación Universitaria de Ciencias de la Salud (FUCS), Facultad de Medicina, Pediatrics Deparment, Universidad Nacional de Colombia (UNAL), Bogotá, Colombia"
      ],
      "name": "Pablo Vasquez-Hoyos"
    },
    {
      "affiliations": [
        "Pediatrics Departament, Sociedad de Cirugía de Bogotá - Hospital de San José",
        "Pediatrics Deparment, Fundación Universitaria de Ciencias de la Salud (FUCS)",
        "Facultad de Medicina, Pediatrics Deparment, Universidad Nacional de Colombia (UNAL), Facultad de Medicina, Fundación Universitaria Sanitas (FUS)",
        "Pediatrics Deparment, Clínica Reina Sofía Pediátrica y Mujer, Bogotá, Colombia"
      ],
      "name": "Jhon Camacho-Cruz"
    },
    {
      "affiliations": [
        "Pediatrics Gastroenterologist, Unidad de Gastroenterología, Hepatología y Nutrición Pediátrica - Gastronutriped, Universidad Nacional de La Pampa (UNLPam), Santa Rosa, Argentina"
      ],
      "name": "Wilson Daza-Carreño"
    }
  ],
  "title": "Eosinophilic esophagitis in Colombian children: relationship between food allergens, symptoms and endoscopic findings",
  "uid": "85c411bd-bda2-5129-b5b5-4602fdf4c5c2"
}