{
  "abstract": "Objective We compared bone structure and body composition in adolescents with a challenge-confirmed cow’s milk allergy (CMA) during infancy to peers with refuted CMA and to controls.Design An observational clinical cohort study.Setting A tertiary allergy clinic at Helsinki University Hospital.Patients From a randomised controlled trial from 1999 to 2001 evaluating the effect of probiotics on atopic eczema, we followed up participants (n=81) at 15–18 years’ age and recruited age-matched controls (n=49). Original study participants all had atopic eczema, and CMA confirmed (n=43) or refuted (n=38) by double-blind placebo-controlled cow’s milk challenge in infancy.Main outcome measures The primary outcome was differences in volumetric bone mineral density (vBMD) measured with peripheral quantitative CT. Secondary outcomes were differences in body composition by a bioelectric impedance analysis.Results Participant’s median age was 17.3 years, 62% were females. After adjusting for sex, age-adjusted body mass index, past 5 years’ mean daily supervised physical activity, daily vitamin D intake from food and supplements and mean daily intake of dairy products, the CMA-confirmed group had, compared with the CMA-refuted group, lower median total vBMD at the distal radius (Z-scores −1.49 vs −0.78). The CMA-confirmed group had lower median total vBMD (Z-scores −0.05 vs +0.01) and lower median trabecular vBMD (Z-scores +0.20 vs +0.51) at the distal tibia compared with controls. No group differences in body composition were found.Conclusion An early childhood history of CMA may be associated with lower adolescent radial and tibial vBMD. Further studies are needed to assess this potential association.",
  "authors": [
    {
      "affiliations": [
        "Children's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"
      ],
      "name": "Sonja Piippo"
    },
    {
      "affiliations": [
        "Children's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"
      ],
      "name": "Tero Varimo"
    },
    {
      "affiliations": [
        "Children's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland",
        "Research Program for Clinical and Molecular Metabolism (CAMM), Faculty of Medicine, University of Helsinki, Helsinki, Finland",
        "Clinical Medicine Research unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland"
      ],
      "name": "Helena Hauta-alus"
    },
    {
      "affiliations": [
        "Children's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"
      ],
      "name": "Mirva Viljanen"
    },
    {
      "affiliations": [
        "Children's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"
      ],
      "name": "Erkki Savilahti"
    },
    {
      "affiliations": [
        "Children's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland",
        "Research Program for Clinical and Molecular Metabolism (CAMM), Faculty of Medicine, University of Helsinki, Helsinki, Finland"
      ],
      "name": "Outi Mäkitie"
    },
    {
      "affiliations": [
        "Children's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"
      ],
      "name": "Mikael Kuitunen"
    }
  ],
  "title": "Bone structure and body composition in adolescents with cow’s milk allergy in infancy: a clinical cohort study",
  "uid": "24956883-cff6-5168-840b-2b52fea6d0dd"
}