{
  "abstract": "Background Wilms tumour is the most common paediatric renal malignancy. The RNA demethylase alkylation repair homologue protein 5 ( ALKBH5), known for its role in reversing N6-methyladenosine modification, has been increasingly implicated in tumourigenesis. Its specific role in Wilms tumour, however, remains largely unexplored. We conducted a case–control study to investigate the association between ALKBH5 gene polymorphisms and susceptibility to Wilms tumour.Methods Our study included 416 patients and 936 cancer-free controls from East China. We genotyped two ALKBH5 single-nucleotide polymorphisms: rs1378602 G>A and rs8400 G>A.Results We found that the rs8400 AA genotype was significantly associated with an increased risk of Wilms tumour compared with GG/GA carriers (adjusted OR=1.39, 95% CI 1.04 to 1.85, p=0.025). Furthermore, individuals carrying two risk genotypes faced a significantly higher risk than those with zero or one risk genotype (adjusted OR=1.43, 95% CI 1.07 to 1.92, p=0.017). Stratified analysis revealed that this elevated risk was particularly pronounced in specific subgroups: children older than 18 months, females and those diagnosed with clinical stages I and II.Conclusion Our findings suggest that the ALKBH5 rs8400 G>A polymorphism is associated with increased susceptibility to Wilms tumour in the Eastern Chinese paediatric population.",
  "authors": [
    {
      "affiliations": [
        "Qingdao Women and Children’s Hospital, Qingdao, China"
      ],
      "name": "Jiabin Yu"
    },
    {
      "affiliations": [
        "Department of Pathology, Anhui Provincial Children’s Hospital, Hefei, China中国合肥安徽省儿童医院病理科"
      ],
      "name": "Yizhen Wang"
    },
    {
      "affiliations": [
        "Nanchang University Jiangxi Provincial Children’s Hospital, Nanchang, China"
      ],
      "name": "Shouhua Zhang"
    },
    {
      "affiliations": [
        "Department of Hematology, Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China"
      ],
      "name": "Haixia Zhou"
    },
    {
      "affiliations": [
        "Department of Pediatric Surgery, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China"
      ],
      "name": "Shaohua He"
    },
    {
      "affiliations": [
        "Department of Pediatric Surgery, Guangzhou Medical University, Guangzhou, China"
      ],
      "name": "Ruixi Hua"
    },
    {
      "affiliations": [
        "Department of Pediatric Surgery, Xinjiang Medical University First Clinical College, Urumqi, China"
      ],
      "name": "Wanfu Li"
    },
    {
      "affiliations": [
        "Department of Pathology, Children’s Hospital of Nanjing Medical University, Nanjing, China"
      ],
      "name": "Chunlei Zhou"
    },
    {
      "affiliations": [
        "Department of Pediatric Surgery, Qingdao Women and Children’s Hospital, Qingdao, China"
      ],
      "name": "Hongting Lu"
    }
  ],
  "title": "ALKBH5 gene polymorphisms and Wilms tumour susceptibility in children from East China: a case–control study",
  "uid": "e6be28d1-71fa-5362-af4d-5ab92aa1d558"
}