{
  "abstract": "Introduction Childhood mortality rates following hospital discharge may outpace inpatient mortality rates in some sub-Saharan African settings. Broadly validated risk assessment tools and biomarkers to identify children at risk for post-discharge mortality (PDM) are lacking. Moreover, clinical diagnoses (eg, pneumonia, sepsis, etc.) that confer high risk of PDM share a common pathobiology that culminates in endothelial dysfunction. The objectives of this study are to (1) externally validate existing risk assessment tools for PDM at 60 days and (2) test the association between a marker of endothelial dysfunction (ie, the global arginine bioavailability ratio [GABR]) and 60-day PDM among young children.Methods and analysis This is a prospective, observational cohort study of neonates (aged 0–28 days, n=1000) and infants and children (aged 1–59 months, n=1000) consecutively discharged from two hospitals in Western Kenya (ie, Jaramogi Oginga Odinga Teaching and Referral Hospital [JOOTRH] and Siaya County Referral Hospital). Candidate variables for previously developed risk assessment tools identified through a systematic review and plasma samples will be collected on the day of hospital discharge. Caregivers of participants will receive telephone calls 30 days and 60 days following discharge to ascertain participants’ vital status. Test characteristics and area under the receiver operating characteristic curves will be calculated for each risk tool to determine their discriminatory value. Risk predictiveness and calibration of each tool will also be determined. Mean and median levels of GABR will be compared between cases and matched controls, and conditional logistic regression will be used to test the association between GABR and PDM.Ethics and dissemination This protocol has received clearance from the Kenya Medical Research Institute Scientific Ethics Review Unit, the JOOTRH Ethics Research Committee, and the Emory University institutional review board. Our results will be disseminated through scientific presentations at national and international conferences and peer-reviewed publications.",
  "authors": [
    {
      "affiliations": [
        "Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya"
      ],
      "name": "Kitiezo Aggrey Igunza"
    },
    {
      "affiliations": [
        "Pediatric Biostatistics Core, Department of Pediatrics, Emory University, Atlanta, Georgia, USA"
      ],
      "name": "Adrianna L Westbrook"
    },
    {
      "affiliations": [
        "Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya"
      ],
      "name": "Harun Owuor"
    },
    {
      "affiliations": [
        "Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"
      ],
      "name": "Enrico M Novelli"
    },
    {
      "affiliations": [
        "Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya"
      ],
      "name": "Richard Omore"
    },
    {
      "affiliations": [
        "Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA",
        "Infectious Diseases and Oncology Research Institute, University of the Witwatersrand, Johannesburg, South Africa"
      ],
      "name": "Robert F Breiman"
    },
    {
      "affiliations": [
        "Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya",
        "Liverpool School of Tropical Medicine, Liverpool, UK"
      ],
      "name": "Victor Akelo"
    },
    {
      "affiliations": [
        "Division of Emergency Medicine, Ann and Robert H Lurie Children’s Hospital of Chicago, Chicago, Illinois, USA",
        "Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA"
      ],
      "name": "Todd A Florin"
    },
    {
      "affiliations": [
        "Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya"
      ],
      "name": "Cynthia Akinyi Onyango"
    },
    {
      "affiliations": [
        "Division of Translational Biomedical Informatics, Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA"
      ],
      "name": "Rishikesan Kamaleswaran"
    },
    {
      "affiliations": [
        "Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya"
      ],
      "name": "Prisca Ngoga Akinyi"
    },
    {
      "affiliations": [
        "Departments of Nutrition and Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA",
        "Center for Nutrition, Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA",
        "Margaret C. Ryan Program in Global Health, Boston Children's Hospital, Boston, Massachusetts, USA"
      ],
      "name": "Christopher P Duggan"
    },
    {
      "affiliations": [
        "Department of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania"
      ],
      "name": "Karim P Manji"
    },
    {
      "affiliations": [
        "Child Health and Mortality Prevention Surveillance Network Program Office, Task Force for Global Health, Atlanta, Georgia, USA"
      ],
      "name": "Cynthia G Whitney"
    },
    {
      "affiliations": [
        "Division of Pediatric Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, USA",
        "Division of Pediatric Emergency Medicine, Children’s Healthcare of Atlanta, Atlanta, Georgia, USA"
      ],
      "name": "Claudia R Morris"
    },
    {
      "affiliations": [
        "Division of Pediatric Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, USA",
        "Division of Pediatric Emergency Medicine, Children’s Healthcare of Atlanta, Atlanta, Georgia, USA"
      ],
      "name": "Chris A Rees"
    }
  ],
  "title": "Advancing approaches to identify young children at risk for post-discharge mortality: Protocol for a prospective observational cohort study in Western Kenya",
  "uid": "68cddd1d-47e5-5778-848f-b0de2756854f"
}