{
  "abstract": "Adolescents and young adults (AYAs) with leukaemia represent a unique population but face fragmented care between paediatric and adult systems. A retrospective study of AYA patients (≥14 years old) with leukaemia treated at Shanghai Children’s Medical Center between September 2023 and March 2025 found acute lymphoblastic leukaemia (ALL) was predominant (152/189). AYA ALL patients showed a higher prevalence of high-risk subtypes like T-ALL and BCR::ABL1, while favourable ETV6::RUNX1 was rare. Paediatric protocols achieved a 5-year event-free survival of 75.2% and overall survival of 89.6%, comparable to young children. These findings show that paediatric-based therapy for AYA ALL can be effective, although prospective comparative studies are still needed.",
  "authors": [
    {
      "affiliations": [
        "Key Laboratory of Pediatric Hematology & Oncology of the Ministry of Health of China, Department of Hematology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China",
        "Research Division for Health Administration and Smart Healthcare, Child Health Advocacy Institute, China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai, China"
      ],
      "name": "Kefei Wu"
    },
    {
      "affiliations": [
        "Department of Hematology, Huadong Hospital Affiliated to Fudan University, Shanghai, China"
      ],
      "name": "Wensi Qian"
    },
    {
      "affiliations": [
        "Key Laboratory of Pediatric Hematology & Oncology of the Ministry of Health of China, Department of Hematology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"
      ],
      "name": "Kunlin Pei"
    },
    {
      "affiliations": [
        "Key Laboratory of Pediatric Hematology & Oncology of the Ministry of Health of China, Department of Hematology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"
      ],
      "name": "Zhuo Wang"
    },
    {
      "affiliations": [
        "Key Laboratory of Pediatric Hematology & Oncology of the Ministry of Health of China, Department of Hematology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"
      ],
      "name": "Changcheng Chen"
    },
    {
      "affiliations": [
        "Key Laboratory of Pediatric Hematology & Oncology of the Ministry of Health of China, Department of Hematology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"
      ],
      "name": "Shuhong Shen"
    },
    {
      "affiliations": [
        "Research Division for Health Administration and Smart Healthcare, Child Health Advocacy Institute, China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai, China"
      ],
      "name": "Hao Zhang"
    },
    {
      "affiliations": [
        "Research Division for Health Administration and Smart Healthcare, Child Health Advocacy Institute, China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai, China"
      ],
      "name": "Jiajun Yuan"
    },
    {
      "affiliations": [
        "National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China"
      ],
      "name": "Yao Yao"
    },
    {
      "affiliations": [
        "Key Laboratory of Pediatric Hematology & Oncology of the Ministry of Health of China, Department of Hematology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"
      ],
      "name": "Wenting Hu"
    }
  ],
  "title": "Continuity of paediatric care for adolescents and young adults with leukaemia: a single-centre experience from China",
  "uid": "037910d7-8a31-5491-995a-22af2c1d8013"
}