{
  "abstract": "Introduction Long COVID is a frequent post-infectious chronic condition that impacts quality of life and work performance. Whether individuals with comorbidities experience a greater functional impact of long COVID is unknown. We evaluated the functional impact of long COVID among healthcare workers (HCWs) with chronic cardiovascular diseases, chronic respiratory diseases, obesity or a history of depression, and compared it with that of HCWs without comorbidities.Methods We conducted a cross-sectional study in Quebec, Canada. We compared self-reported long COVID cases to COVID-19-infected controls without long COVID on work ability, work functioning, health-related absenteeism, dyspnoea-associated impairment and psychological distress among HCWs (a) with at least one of the four comorbidities, (b) with each of the four comorbidities and (c) without comorbidities. We used inverse probability of exposure and robust Poisson regressions to estimate adjusted prevalence differences (aPD) and prevalence ratios. Comorbidity data were obtained from the Quebec integrated chronic disease surveillance system.Results A total of 3754 and 8439 HCWs with and without comorbidities, respectively, were included. Among HCWs with at least one of the four comorbidities, long COVID was associated with higher prevalence of low work ability (aPD=15%, 95% CI: 12% to 18%), low work functioning (aPD=27%, 95% CI: 22% to 31%), health-related long-term absenteeism (aPD=8%, 95% CI: 5% to 11%), dyspnoea-associated impairment (aPD=23%, 95% CI: 19% to 26%) and psychological distress (aPD=24%, 95% CI: 20% to 28%). aPDs were greater among HCWs with comorbidities than among those without for low work ability (p=0.013 for interaction), for low work functioning (p=0.034) and for dyspnoea-associated impairment (p<0.001).Conclusion Long COVID is associated with significant functional impairment among HCWs with pre-existing chronic conditions. HCWs with at least one of the four comorbidities experience lower work ability, lower work functioning and more dyspnoea-associated impairment compared with those without comorbidities.",
  "authors": [
    {
      "affiliations": [
        "Department of Social and Preventive Medicine, Laval University, Québec City, Quebec, Canada",
        "Centre de recherche du CHUQ, Québec City, Quebec, Canada"
      ],
      "name": "Sabine Isangwe"
    },
    {
      "affiliations": [
        "Department of Social and Preventive Medicine, Laval University, Québec City, Quebec, Canada",
        "Centre de recherche du CHUQ, Québec City, Quebec, Canada"
      ],
      "name": "Denis Talbot"
    },
    {
      "affiliations": [
        "Centre de recherche Charles-Le Moyne, Montreal, Quebec, Canada"
      ],
      "name": "Marie-France Coutu"
    },
    {
      "affiliations": [
        "Direction de la santé environnementale, Quebec National Institute of Public Health, Québec City, Quebec, Canada"
      ],
      "name": "Elisabeth Canitrot"
    },
    {
      "affiliations": [
        "Faculty de Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Quebec, Canada",
        "Centre de recherche du CHUS, CIUSSS de l’Estrie CHUS, Sherbrooke, Quebec, Canada"
      ],
      "name": "Simon Décary"
    },
    {
      "affiliations": [
        "Center for Immunity, Inflammation and Infectious Diseases, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada",
        "Department of Medicine, University of Montreal, Montreal, Quebec, Canada"
      ],
      "name": "Emilia Liana Falcone"
    },
    {
      "affiliations": [
        "Quebec National Institute of Public Health, Québec City, Quebec, Canada"
      ],
      "name": "Manale Ouakki"
    },
    {
      "affiliations": [
        "Centre de recherche du CHUQ, Québec City, Quebec, Canada"
      ],
      "name": "Philippe Latouche"
    },
    {
      "affiliations": [
        "Faculty de Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Quebec, Canada",
        "Centre de recherche du CHUS, CIUSSS de l’Estrie CHUS, Sherbrooke, Quebec, Canada"
      ],
      "name": "Alain Piché"
    },
    {
      "affiliations": [
        "Department of Social and Preventive Medicine, Laval University, Québec City, Quebec, Canada",
        "Quebec National Institute of Public Health, Québec City, Quebec, Canada"
      ],
      "name": "Marc Simard"
    },
    {
      "affiliations": [
        "The Charles-Le Moyne Research Center, Montreal, Quebec, Canada",
        "School of Rehabilitation, University of Sherbrooke -Longueuil Campus, Montreal, Quebec, Canada"
      ],
      "name": "Marianne Balem"
    },
    {
      "affiliations": [
        "Department of Social and Preventive Medicine, Laval University, Québec City, Quebec, Canada"
      ],
      "name": "Gaston De Serres"
    },
    {
      "affiliations": [
        "Department of Social and Preventive Medicine, Laval University, Québec City, Quebec, Canada",
        "Quebec National Institute of Public Health, Québec City, Quebec, Canada"
      ],
      "name": "Sara Carazo"
    }
  ],
  "title": "Functional impact of long COVID among healthcare workers with comorbidities in Quebec, Canada: a cross-sectional study",
  "uid": "00713110-de9d-531a-9a2f-35f38e0be632"
}