{
  "abstract": "Dengue is a global health emergency, with annually increasing case numbers that overwhelm healthcare systems, an ever-expanding range of the mosquito vector, and no antiviral or host-directed treatments proven to alter the course of disease. This article reports on a meeting of the Dengue Therapeutics Consortium, which included attendees from 19 countries with backgrounds in basic science, clinical research, drug development, industry, clinical trial methodology and policy. We summarise the current state of dengue therapeutics research and highlight the necessary steps to ensure that patients have equitable access to affordable and effective treatments. We review the antiviral pipeline, including novel and repurposed antiviral candidates, and we propose both human challenge and rate of viral clearance studies as methods to rapidly screen for antiviral activity prior to larger phase 3 clinical trials. We review ongoing phase 2 and phase 3 clinical trials to evaluate repurposed host-directed therapies for patients with moderate and severe disease, and we suggest considerations for future trial design, such as factorial randomisation and the use of a core outcome set to maximise efficiency and enable evidence synthesis by meta-analysis. We consider that multisectoral collaboration will be essential to achieve our aim of effective treatments for dengue. This will include drug development aligned to target product profiles, conduct of clinical trials with endpoints acceptable to both patients and regulators and sustained commitment from the pharmaceutical industry, non-profit initiatives and policymakers to ensure that effective treatments reach those who need them the most.",
  "authors": [
    {
      "affiliations": [
        "University of Oxford, Oxford, UK"
      ],
      "name": "Angela McBride"
    },
    {
      "affiliations": [
        "Oxford University Clinical Research Unit Vietnam, Ho Chi Minh City, Vietnam"
      ],
      "name": "Ho Quang Chanh"
    },
    {
      "affiliations": [
        "Paediatric Intensive Care Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam"
      ],
      "name": "Huynh Trung Trieu"
    },
    {
      "affiliations": [
        "Oxford University Clinical Research Unit Vietnam, Ho Chi Minh City, Vietnam"
      ],
      "name": "Huyen Bang Tran"
    },
    {
      "affiliations": [
        "State University of New York Upstate Medical University, Syracuse, New York, USA"
      ],
      "name": "Kathryn B Anderson"
    },
    {
      "affiliations": [
        "Viral Epidemiology and Immunity Unit, National Institute of Allergy and Infectious Diseases Laboratory of Infectious Diseases, Bethesda, Maryland, USA"
      ],
      "name": "Rosemary A Aogo"
    },
    {
      "affiliations": [
        "Mahidol University, Bangkok, Thailand"
      ],
      "name": "Panisadee Avirutnan"
    },
    {
      "affiliations": [
        "Oxford University Clinical Research Unit Vietnam, Ho Chi Minh City, Vietnam"
      ],
      "name": "Luu Hoai Bao Tran"
    },
    {
      "affiliations": [
        "University of Oxford, Oxford, UK"
      ],
      "name": "Xin Hui Chan"
    },
    {
      "affiliations": [
        "Novartis Pharmaceuticals, Basel, Switzerland"
      ],
      "name": "Richa Chandra"
    },
    {
      "affiliations": [
        "The George Washington University, Washington, District of Columbia, USA"
      ],
      "name": "Aileen Chang"
    },
    {
      "affiliations": [
        "Tan Tock Seng Hospital National Centre for Infectious Diseases, Singapore"
      ],
      "name": "Po Ying Chia"
    },
    {
      "affiliations": [
        "Drugs for Neglected Diseases initiative South-East Asia, Federal Territory of Kuala Lumpur, Malaysia"
      ],
      "name": "Vanessa Daniel"
    },
    {
      "affiliations": [
        "Independent Researcher, Limassol, Cyprus"
      ],
      "name": "Anastasiia Demidova"
    },
    {
      "affiliations": [
        "Centro de Atención y Diagnóstico de Enfermedades Infecciosas, Bucaramanga, Colombia"
      ],
      "name": "Monika Patricia Consuegra Rodriguez"
    },
    {
      "affiliations": [
        "Instituto de Infectologia Emílio Ribas, São Paulo, Brazil"
      ],
      "name": "Claudia Figueiredo-Mello"
    },
    {
      "affiliations": [
        "University of Oxford, Oxford, UK"
      ],
      "name": "Esteban Garcia-Gallo"
    },
    {
      "affiliations": [
        "Wellcome Trust, London, UK"
      ],
      "name": "William Garrood"
    },
    {
      "affiliations": [
        "Oxford University Clinical Research Unit Vietnam, Ho Chi Minh City, Vietnam"
      ],
      "name": "Dong Thi Hoai Tam"
    },
    {
      "affiliations": [
        "Center for Global Health, Colorado School of Public Health, Aurora, Colorado, USA",
        "Heidelberg Institute for Global Health, UniversitatsKlinikum Heidelberg, Heidelberg, Germany"
      ],
      "name": "Thomas Jaenisch"
    },
    {
      "affiliations": [
        "Institute of Naval Medicine, Alverstoke, England, UK"
      ],
      "name": "Matthew Kain"
    },
    {
      "affiliations": [
        "Viral Epidemiology and Immunity Unit, National Institute of Allergy and Infectious Diseases Laboratory of Infectious Diseases, Bethesda, Maryland, USA"
      ],
      "name": "Leah Katzelnick"
    },
    {
      "affiliations": [
        "Saw Swee Hock School of Public Health, National University of Singapore, Singapore"
      ],
      "name": "Phung Khanh Lam"
    },
    {
      "affiliations": [
        "Mahidol Oxford Tropical Medicine Research Unit, Bangkok, Thailand"
      ],
      "name": "Stije J Leopold"
    },
    {
      "affiliations": [
        "Clinical Monitoring Research Program Directorate, National Cancer Institute Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA"
      ],
      "name": "Caeul Lim"
    },
    {
      "affiliations": [
        "Drugs for Neglected Diseases Initiative, Geneva, Switzerland"
      ],
      "name": "Andre M Siqueira"
    },
    {
      "affiliations": [
        "Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura, Nugegoda, Sri Lanka"
      ],
      "name": "Gathsaurie Neelika Malavige"
    },
    {
      "affiliations": [
        "Drugs for Neglected Diseases Initiative, Geneva, Switzerland"
      ],
      "name": "Shikha Malik"
    },
    {
      "affiliations": [
        "Public Health Department, Institut Pasteur de Dakar, Dakar, Senegal"
      ],
      "name": "Laura Merson"
    },
    {
      "affiliations": [
        "Novartis Pharmaceuticals, Basel, Switzerland"
      ],
      "name": "Isabelle Meyer-Andrieux"
    },
    {
      "affiliations": [
        "The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"
      ],
      "name": "Nathaniel Moorman"
    },
    {
      "affiliations": [
        "National Institutes of Health, Bethesda, Maryland, USA"
      ],
      "name": "Aaron Neal"
    },
    {
      "affiliations": [
        "Oxford University Clinical Research Unit Vietnam, Ho Chi Minh City, Vietnam"
      ],
      "name": "Nguyet Minh Nguyen"
    },
    {
      "affiliations": [
        "Universiti Malaya, Federal Territory of Kuala Lumpur, Malaysia"
      ],
      "name": "Hang-Cheng Ong"
    },
    {
      "affiliations": [
        "Medical Research Council Clinical Trials Unit at University College London, London, UK"
      ],
      "name": "Sarah Pett"
    },
    {
      "affiliations": [
        "Centro de Atención y Diagnóstico de Enfermedades Infecciosas, Bucaramanga, Colombia"
      ],
      "name": "Elsa Rojas-Garrido"
    },
    {
      "affiliations": [
        "Mahidol Oxford Tropical Medicine Research Unit, Bangkok, Thailand"
      ],
      "name": "William Schilling"
    },
    {
      "affiliations": [
        "International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh"
      ],
      "name": "Lubaba Shahrin"
    },
    {
      "affiliations": [
        "Drugs for Neglected Diseases Initiative, Geneva, Switzerland"
      ],
      "name": "Peter Sjo"
    },
    {
      "affiliations": [
        "Universiti Malaya, Federal Territory of Kuala Lumpur, Malaysia"
      ],
      "name": "Sharifah Faridah Syed Omar"
    },
    {
      "affiliations": [
        "Center for Advanced and Innovative Therapies, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"
      ],
      "name": "Mauro Teixeira"
    },
    {
      "affiliations": [
        "Critical Care, Apollo Hospital Chennai, Chennai, India"
      ],
      "name": "Bharath Kumar Tirupakuzhi Vijayaraghavan"
    },
    {
      "affiliations": [
        "Centro de Atención y Diagnóstico de Enfermedades Infecciosas, Bucaramanga, Colombia"
      ],
      "name": "Luis Villar"
    },
    {
      "affiliations": [
        "Oxford University Clinical Research Unit Vietnam, Ho Chi Minh City, Vietnam",
        "University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam"
      ],
      "name": "Nguyen Lam Vuong"
    },
    {
      "affiliations": [
        "State University of New York Upstate Medical University, Syracuse, New York, USA"
      ],
      "name": "Adam Waickman"
    },
    {
      "affiliations": [
        "University of Oxford, Oxford, UK"
      ],
      "name": "Bridget Wills"
    },
    {
      "affiliations": [
        "University of Oxford, Oxford, UK",
        "Oxford University Clinical Research Unit Vietnam, Ho Chi Minh City, Vietnam"
      ],
      "name": "Evelyne Kestelyn"
    },
    {
      "affiliations": [
        "University of Oxford, Oxford, UK"
      ],
      "name": "James Watson"
    },
    {
      "affiliations": [
        "King’s College London, London, UK",
        "Department of Paediatrics and Paediatric Infectious Diseases, I M Sechenov First Moscow State Medical University, Moscow, Russian Federation"
      ],
      "name": "Daniel Borisovich Munblit"
    },
    {
      "affiliations": [
        "University of Oxford, Oxford, UK",
        "Oxford University Clinical Research Unit Vietnam, Ho Chi Minh City, Vietnam"
      ],
      "name": "Sophie Yacoub"
    }
  ],
  "title": "Dengue therapeutics consortium 2025: a global collaboration in action",
  "uid": "d52e9a9f-4955-51ec-9396-6caa85123b19"
}