{
  "abstract": "Introduction Preparation for a future pandemic or serious epidemic caused by a known or yet unknown pathogen (Disease X) is a global health priority. Controlled human infection studies (CHIS) are recognised as a valuable tool to accelerate development of vaccines and immunotherapeutics against pathogens with pandemic potential and may play a role in future pandemic settings. The acceptability of CHIS to potential participants in a pandemic setting has not been explored.Methods A mixed-methods study of adults screened to participate in a first-in-human SARS-CoV-2 vaccine trial, using online survey and interviews, was undertaken between September and October 2020 in Oxford, UK. This work assessed individuals’ views, motivations and experiences of participating in a trial during a pandemic setting, including attitudes towards a hypothetical SARS-CoV-2 CHIS.Results 349 of 770 (45%) invited individuals completed the survey, and 102 survey respondents (29%) participated in a structured interview. Participants were highly educated, research informed and predominantly of white ethnicity. Approximately a third of survey respondents agreed they would be willing to participate in a hypothetical SARS-CoV-2 CHIS. Individuals aged <35 years old, those without children and those who were single were more likely to agree to participate in a hypothetical SARS-CoV-2 CHIS. This decision was dependent on short-term and long-term complications of infection, availability of rescue therapy, likelihood of CHIS to accelerate vaccine development and urgency of the public health need. Motivations to participate in a SARS-CoV-2 CHIS included altruism and a preference to acquire infection of a circulating pandemic pathogen in a controlled setting. The views of family and friends were important in individuals’ decision-making.Conclusions Vaccine trial participants are an informed and motivated public group who can provide situated public expertise for CHIS pandemic preparedness. Recruitment to CHIS in a pandemic may be more efficient if targeted to younger, single individuals without children. Media engagement and information specifically for potential CHIS participants’ families is important to facilitate informed discussion.",
  "authors": [
    {
      "affiliations": [
        "Department of Paediatrics, University of Oxford, Oxford, Oxfordshire, UK",
        "NIHR Oxford Biomedical Research Centre, Oxford, UK"
      ],
      "name": "Katherine RW Emary"
    },
    {
      "affiliations": [
        "Department of Paediatrics, University of Oxford, Oxford, Oxfordshire, UK",
        "NIHR Oxford Biomedical Research Centre, Oxford, UK"
      ],
      "name": "Rebecca te Water Naude"
    },
    {
      "affiliations": [
        "Department of Paediatrics, University of Oxford, Oxford, Oxfordshire, UK",
        "NIHR Oxford Biomedical Research Centre, Oxford, UK"
      ],
      "name": "Arabella Stewart"
    },
    {
      "affiliations": [
        "Department of Paediatrics, University of Oxford, Oxford, Oxfordshire, UK",
        "NIHR Oxford Biomedical Research Centre, Oxford, UK"
      ],
      "name": "Maia Patrick-Smith"
    },
    {
      "affiliations": [
        "Department of Paediatrics, University of Oxford, Oxford, Oxfordshire, UK",
        "NIHR Oxford Biomedical Research Centre, Oxford, UK"
      ],
      "name": "John A Henry"
    },
    {
      "affiliations": [
        "Department of Paediatrics, University of Oxford, Oxford, Oxfordshire, UK",
        "NIHR Oxford Biomedical Research Centre, Oxford, UK"
      ],
      "name": "Marcus English"
    },
    {
      "affiliations": [
        "Department of Paediatrics, University of Oxford, Oxford, Oxfordshire, UK",
        "NIHR Oxford Biomedical Research Centre, Oxford, UK"
      ],
      "name": "Tonia M Thomas"
    },
    {
      "affiliations": [
        "Department of Paediatrics, University of Oxford, Oxford, Oxfordshire, UK"
      ],
      "name": "Naomi Douglas"
    },
    {
      "affiliations": [
        "Department of Paediatrics, University of Oxford, Oxford, Oxfordshire, UK",
        "NIHR Oxford Biomedical Research Centre, Oxford, UK"
      ],
      "name": "Maria Moore"
    },
    {
      "affiliations": [
        "Department of Paediatrics, University of Oxford, Oxford, Oxfordshire, UK",
        "NIHR Oxford Biomedical Research Centre, Oxford, UK"
      ],
      "name": "Andrew J Pollard"
    },
    {
      "affiliations": [
        "Department of Paediatrics, University of Oxford, Oxford, Oxfordshire, UK",
        "NIHR Oxford Biomedical Research Centre, Oxford, UK"
      ],
      "name": "Samantha Vanderslott"
    },
    {
      "affiliations": [
        "NIHR Oxford Biomedical Research Centre, Oxford, UK",
        "Jenner Institute, University of Oxford, Oxford, Oxfordshire, UK"
      ],
      "name": "Susanne H Hodgson"
    }
  ],
  "title": "Mixed-methods study assessing the acceptability and feasibility of Human Challenge Studies for Disease X in Healthy UK Adults in a SARS-CoV-2 pandemic setting",
  "uid": "3001b5d9-5d63-5aa2-b4b7-937aa2cd92d7"
}