{
  "abstract": "Purpose Uveitis is a group of intraocular inflammatory conditions that may result in severe visual impairment. The potential interplay between uveitis and socioeconomic factors remains largely unexplored. This study investigated the association between socioeconomic factors and the risk of cardiovascular disease, diabetes and all-cause mortality in patients with uveitis.Design Nationwide cohort study.Methods All patients registered with a uveitis diagnosis at a Danish public hospital between 2000 and 2018 were included and stratified into low, intermediate or high educational or household income level. Data from different registers were linked using a personal identification number. Using the high levels as the reference, we estimated incidence rates and cumulative incidence. We quantified the differences using HRs with 95% CIs for cardiovascular disease, diabetes and all-cause mortality through Cox proportional hazards models.Results In a cohort of 18 225 patients with uveitis, we observed increased rates and risks of all-cause mortality, peripheral artery disease, myocardial infarction, heart failure, ischaemic heart disease, stroke, and diabetes for lower educational or income level. The following HRs (95% CI) were elevated in patients with uveitis with low or intermediate socioeconomic status: all-cause mortality (low status: education: 1.58 (1.30 to 1.90); income: 2.09 (1.70 to 2.59); intermediate status: income: 1.56 (1.25 to 1.94)), diabetes (low status: education: 1.72 (1.33 to 2.23); income: 2.15 (1.65 to 2.79)), peripheral artery disease (low status: education 2.87 (1.77 to 4.68); intermediate status: income: 2.11 (1.35 to 3.30)), myocardial infarction (low status: education: 2.13 (1.32 to 3.44); intermediate status: income: 2.29 (1.40 to 3.75)), heart failure (low status: education: 1.99 (1.33 to 2.96); income: 2.05 (1.35 to 3.11)), ischaemic heart disease (low status: education: 1.62 (1.24 to 2.11)), and stroke (low status: income: 1.70 (1.19 to 2.43)).Conclusion Patients with uveitis with lower educational or income level faced a statistically significantly increased risk of cardiovascular disease, diabetes and mortality. Alongside the direct burden of uveitis, socioeconomic status should also be accounted for when assessing patient risk and designing management strategies.",
  "authors": [
    {
      "affiliations": [
        "Department of Ophthalmology, Aalborg Universitetshospital, Aalborg, Denmark",
        "Department of Clinical Medicine, Aalborg University, Aalborg, Denmark"
      ],
      "name": "Marie Ørskov"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Aalborg Universitetshospital, Aalborg, Denmark",
        "Department of Clinical Medicine, Aalborg University, Aalborg, Denmark"
      ],
      "name": "Henrik Vorum"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Rigshospitalet, Copenhagen, Denmark",
        "Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"
      ],
      "name": "Oliver Niels Klefter"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Rigshospitalet, Copenhagen, Denmark",
        "Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark",
        "Department of Clinical Research, University of Southern Denmark, Odense, Denmark"
      ],
      "name": "Yousif Subhi"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Rigshospitalet, Copenhagen, Denmark",
        "Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"
      ],
      "name": "Steffen Heegaard"
    },
    {
      "affiliations": [
        "School of Medicine, Vita-Salute San Raffaele University, Milan, Italy",
        "Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, Milan, Italy"
      ],
      "name": "Maria Vittoria Cicinelli"
    },
    {
      "affiliations": [
        "Department of Clinical Research, University of Southern Denmark, Odense, Denmark",
        "Department of Ophthalmology, Odense University Hospital, Odense, Denmark"
      ],
      "name": "Jimmi Wied"
    },
    {
      "affiliations": [
        "Eye Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE",
        "Cleveland Clnic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, USA"
      ],
      "name": "Piergiorgio Neri"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Aalborg Universitetshospital, Aalborg, Denmark",
        "Department of Clinical Medicine, Aalborg University, Aalborg, Denmark"
      ],
      "name": "Lasse Jørgensen Cehofski"
    }
  ],
  "title": "Impact of socioeconomic factors on cardiovascular diseases, diabetes and all-cause mortality in patients with uveitis: a Danish cohort study",
  "uid": "ccffdd06-900e-534f-a740-0f84e0deaecb"
}