{
  "abstract": "Purpose Exposure to repetitive head impacts sustained during routine sports participation may result in elevated levels of brain-derived biomarkers (BDM) glial fibrillar acidic protein (GFAP), NFL, total tau and ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) independent of concussion occurrence. However, the extent to which sport career duration and sex influence BDM remains unclear. This cross-sectional study examined whether biological sex and exposure-related variables, including age of first exposure to contact sports and time since most recent concussion, were associated with preseason serum concentrations of four brain-derived biomarkers in healthy contact and collision sport athletes.Methods Male and female collegiate athletes (n=700) participating in contact and collision sports were recruited from six Concussion Assessment, Research and Education (CARE) Consortium sites. Non-fasting venous blood samples were collected during preseason testing, and serum concentrations of GFAP, NFL, UCH-L1 and total tau were quantified. General linear models were used to examine whether biomarker concentrations differed by sex, with sport included as a covariate to account for differences in head impact exposure profiles, age of first exposure (AFE) to contact sports and time since most recent concussion. Separate univariate regressions were conducted within football athletes.Results Sex significantly predicted GFAP (p<0.001, η²=0.123) and NFL (p=0.029, η² =0.042) concentrations, with females exhibiting higher serum levels than males. Neither sport, AFE nor time since concussion significantly influenced biomarker concentrations. No significant predictors were identified for UCH-L1 or total tau. In the football-specific analysis, AFE and time since concussion were not associated with biomarker levels.Conclusion Collegiate females participating in contact and collision sports have significantly higher GFAP and NFL serum concentrations than age-matched and sport-matched males, independent of sport, AFE and time since concussion. These findings may contribute to understanding sex-based biological sensitivity to head impact exposure and support the development of biomarker-informed monitoring strategies in athletes.",
  "authors": [
    {
      "affiliations": [
        "Ohio University, Athens, Ohio, USA"
      ],
      "name": "Melissa Anderson"
    },
    {
      "affiliations": [
        "Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, USA"
      ],
      "name": "Caitlin A Gallo"
    },
    {
      "affiliations": [
        "Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, USA"
      ],
      "name": "Scott W Passalugo"
    },
    {
      "affiliations": [
        "Johns Hopkins University School of Nursing, Baltimore, Maryland, USA"
      ],
      "name": "Jessica Gill"
    },
    {
      "affiliations": [
        "University of Puthisastra, Phnom Penh, Phnom Penh, Cambodia"
      ],
      "name": "Rany Vorn"
    },
    {
      "affiliations": [
        "School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, Ohio, USA"
      ],
      "name": "Jaclyn B Caccese"
    },
    {
      "affiliations": [
        "Keller Army Hospital, West Point, New York, USA"
      ],
      "name": "Kenneth L Cameron"
    },
    {
      "affiliations": [
        "Keller Army Hospital, West Point, New York, USA"
      ],
      "name": "Steven R Malvasi"
    },
    {
      "affiliations": [
        "Extremity Trauma and Amputation Center of Excellence, Joint Base San Antonio Fort Sam Houston, Texas, USA"
      ],
      "name": "Megan H Roach"
    },
    {
      "affiliations": [
        "United States Air Force Academy, Colorado Springs, Colorado, USA"
      ],
      "name": "Jonathan C Jackson"
    },
    {
      "affiliations": [
        "United States Air Force Academy, Colorado Springs, Colorado, USA"
      ],
      "name": "Gerald McGinty"
    },
    {
      "affiliations": [
        "University of Michigan, Ann Arbor, Michigan, USA"
      ],
      "name": "Steven Broglio"
    },
    {
      "affiliations": [
        "Indiana University School of Medicine, Indianapolis, Indiana, USA"
      ],
      "name": "Thomas W McAllister"
    },
    {
      "affiliations": [
        "Medical College of Wisconsin, Milwaukee, Wisconsin, USA"
      ],
      "name": "Michael McCrea"
    },
    {
      "affiliations": [
        "Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA"
      ],
      "name": "Paul F Pasquina"
    },
    {
      "affiliations": [
        "Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, USA"
      ],
      "name": "Thomas A Buckley"
    }
  ],
  "title": "Sex, but not exposure-related variables, predicts baseline serum glial fibrillar acidic protein and neurofilament light levels in contact sport athletes",
  "uid": "a21214c9-b801-50ce-bd38-12ac37e3af08"
}