{
  "abstract": "Introduction People with multiple sclerosis (MS) engage in less physical activity and experience higher rates of osteoporosis, falls and fractures than the general population, contributing to reduced health-related quality of life (HRQoL) and increased healthcare costs. High-intensity resistance and impact training (HiRIT) has beneficial effects on bone, muscle and physical function in other populations, but its effectiveness in people with MS is unclear.Methods and analysis STRONG-MS is a codesigned, clinician-led, single-blind, randomised controlled trial evaluating the effect of a HiRIT programme, ONERO, on HRQoL for people with MS. Secondary aims include assessing changes in bone mineral density, body composition, physical function, fatigue, mood as well as intervention safety, feasibility, acceptability, sustainability and cost-effectiveness. One hundred and eighty participants will be randomised (2:1) to ONERO or usual care for 12 months. The intervention comprises two times weekly, supervised, small-group sessions delivered by accredited allied health professionals. Outcomes will be assessed at 12 and 24 months using intention-to-treat analyses. Sustainability will be evaluated during a second 12-month period, during which participants fund ongoing participation privately or through support schemes.Ethics and dissemination The study has approval from a Health Human Research Ethics Committee. All participants will provide written informed consent. Findings will be disseminated through peer-reviewed publications, conference presentations and summaries for participants, consumer representatives and community organisations. This study will provide novel evidence on the ability of the ONERO to improve HRQoL and musculoskeletal health in people with MS as well as its feasibility, acceptability and sustainability, to inform poststudy implementation.",
  "authors": [
    {
      "affiliations": [
        "School of Psychology, Faculty of Health, Deakin University, Burwood, Victoria, Australia",
        "Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia"
      ],
      "name": "Lisa Grech"
    },
    {
      "affiliations": [
        "Griffith University, Gold Coast, Queensland, Australia",
        "The Bone Clinic, Brisbane, Queensland, Australia"
      ],
      "name": "Belinda Beck"
    },
    {
      "affiliations": [
        "Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia",
        "Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia"
      ],
      "name": "David Scott"
    },
    {
      "affiliations": [
        "Nutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia",
        "Medical School, The University of Western Australia, Perth, Western Australia, Australia"
      ],
      "name": "Marc Sim"
    },
    {
      "affiliations": [
        "Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia",
        "Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia"
      ],
      "name": "Jakub Mesinovic"
    },
    {
      "affiliations": [
        "Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia",
        "Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia"
      ],
      "name": "Paul Jansons"
    },
    {
      "affiliations": [
        "Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia"
      ],
      "name": "Fernanda Rodrigues Fonseca"
    },
    {
      "affiliations": [
        "Deakin Health Economics, School of Health and Social Development, Institute for Health Transformation, Faculty of Health, Deakin University, Geelong, Victoria, Australia"
      ],
      "name": "Julie Abimanyi-Ochom"
    },
    {
      "affiliations": [
        "Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia",
        "Frankston Neurology, Frankston, Victoria, Australia"
      ],
      "name": "Michelle Allan"
    },
    {
      "affiliations": [
        "Brisbane Neurology, South Brisbane, Queensland, Australia"
      ],
      "name": "Stefan Blum"
    },
    {
      "affiliations": [
        "Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia",
        "Frankston Hospital, Peninsula Health, Frankston, Victoria, Australia"
      ],
      "name": "Ernest Butler"
    },
    {
      "affiliations": [
        "Perron Institute for Neurological and Translational Science, Nedlands, Western Australia, Australia"
      ],
      "name": "William Carroll"
    },
    {
      "affiliations": [
        "People with MS Victoria, Blackburn, Victoria, Australia"
      ],
      "name": "Nigel Caswell"
    },
    {
      "affiliations": [
        "Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia"
      ],
      "name": "Peter Ebeling"
    },
    {
      "affiliations": [
        "Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia"
      ],
      "name": "Vanessa Gan"
    },
    {
      "affiliations": [
        "Monash University Clinical Trials Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia"
      ],
      "name": "Alan Herschtal"
    },
    {
      "affiliations": [
        "Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia",
        "Department of Neurology, Monash Health, Clayton, Victoria, Australia"
      ],
      "name": "Nevin John"
    },
    {
      "affiliations": [
        "Perron Institute for Neurological and Translational Science, Nedlands, Western Australia, Australia",
        "The University of Western Australia, Perth, Western Australia, Australia"
      ],
      "name": "Allan Kermode"
    },
    {
      "affiliations": [
        "Perron Institute for Neurological and Translational Science, Nedlands, Western Australia, Australia"
      ],
      "name": "Linh Le-Kavanagh"
    },
    {
      "affiliations": [
        "Deakin Health Economics, School of Health and Social Development, Institute for Health Transformation, Faculty of Health, Deakin University, Geelong, Victoria, Australia"
      ],
      "name": "Shalika Bohingamu Mudiyanselage"
    },
    {
      "affiliations": [
        "People with MS Victoria, Blackburn, Victoria, Australia"
      ],
      "name": "Lynne Elizabeth Ohman"
    },
    {
      "affiliations": [
        "Private Lived Experience Consultant, Perth, Western Australia, Australia"
      ],
      "name": "Mia Poposka"
    },
    {
      "affiliations": [
        "People with MS Victoria, Blackburn, Victoria, Australia"
      ],
      "name": "Alison Reece"
    },
    {
      "affiliations": [
        "Department of Physiotherapy, Monash Health, Clayton, Victoria, Australia"
      ],
      "name": "Phoebe Sansom"
    },
    {
      "affiliations": [
        "Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia",
        "Department of Physiotherapy, Monash Health, Clayton, Victoria, Australia"
      ],
      "name": "Charlotte Scroggie"
    },
    {
      "affiliations": [
        "School of Psychology, Faculty of Health, Deakin University, Burwood, Victoria, Australia"
      ],
      "name": "Christopher Todaro"
    },
    {
      "affiliations": [
        "Deakin Health Economics, School of Health and Social Development, Institute for Health Transformation, Faculty of Health, Deakin University, Geelong, Victoria, Australia"
      ],
      "name": "Jennifer Watts"
    },
    {
      "affiliations": [
        "Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia"
      ],
      "name": "Ayse Zengin"
    }
  ],
  "title": "Clinician-led, single-blind, randomised controlled trial evaluating the efficacy of a high-intensity resistance and impact training intervention for improving health-related quality of life in people with multiple sclerosis: protocol for STRONG-MS",
  "uid": "4edeb343-bcf4-581f-9ad1-0d7b93805724"
}