{
  "abstract": "Objective To evaluate the safety and efficacy of the EndoArt® artificial endothelial implant in patients unsuitable for conventional endothelial keratoplasty.Methods This retrospective interventional case series included 10 eyes of 10 patients undergoing EndoArt implantation between December 2024 and September 2025. Primary outcome measures were best-corrected visual acuity (BCVA) and central corneal thickness (CCT). Secondary outcomes included additional interventions and incidence of adverse events.Results Six patients (60%) had previous keratoplasty, four (40%) with multiple (2–4) failed grafts. Nine patients (90%) had prior glaucoma filtration surgery, three (30%) were aphakic. Indications for surgery were visual rehabilitation in four eyes (40%) and symptom relief in six (60%). All patients had significant vision-limiting ocular comorbidities. Mean follow-up was 6.9 months (range 3–12). Five eyes (50%) required at least one re-intervention (rebubbling or suture adjustment), and four underwent multiple (2–4) procedures. All implants were fully attached at final follow-up. Mean pre-operative BCVA and CCT were 1.95 logMAR (range 1.0–PL) and 787 ± 93 µm, improving post-operatively to 1.85 logMAR (range 0.34–NPL) and 651±183 µm, respectively. In eyes treated for visual rehabilitation, BCVA improved from 1.67 logMAR (range 1.1–HM) to 0.90 logMAR (range 0.34–1.3), with CCT decreasing from 786±112 µm to 581±103 µm. All patients treated for comfort experienced complete resolution of symptoms.Conclusions EndoArt® offers a promising donor-free option for highly complex eyes unsuitable for keratoplasty. Early outcomes are influenced by the substantial comorbidity burden of this cohort.",
  "authors": [
    {
      "affiliations": [
        "Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK"
      ],
      "name": "Poonam Sharma"
    },
    {
      "affiliations": [
        "Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK"
      ],
      "name": "Harry Roberts"
    },
    {
      "affiliations": [
        "Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK"
      ],
      "name": "Leo Feinberg"
    },
    {
      "affiliations": [
        "Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK"
      ],
      "name": "Shakeel Ahmad"
    }
  ],
  "title": "OP14 Early experience of EndoArt in the United Kingdom: a case series of 10 eyes",
  "uid": "bc0dec64-0a48-5de6-93de-ae02ff161b85"
}