{
  "abstract": "Aims Evaluate the efficacy and safety of faricimab for treatment-naïve and pre-treated diabetic macular oedema (DME) in a real-world setting.Methods This multicentre, retrospective cohort study examined consecutive DME patients treated with faricimab for ≥1 year. Data were collected at predefined time points. Primary outcomes were mean changes in corrected visual acuity (VA), centre-point retinal thickness (CRT) and central subfield thickness (CST) and treatment intervals and adverse events (AEs).Results 184 eyes with DME were included: 61 (33.2%) were treatment-naïve, and 123 (66.8%) were pretreated. In treatment-naïve eyes, VA improved from 69.7±15 Early Treatment of Diabetic Retinopathy Study letters at baseline to 73.9±14.1 after 12 months (p=0.014), while it remained stable in pretreated eyes (71.2±14.2 vs 73.0±12.9; p=0.14). CST decreased significantly in both groups (treatment-naïve (366.1±108.3 µm to 316.4±113.5 µm, p<0.001); pretreated (339.1±93.1 µm to 298.3±65.8 µm, p<0.001)). Thirty-one percent of naïve eyes and 21.1% of pretreated eyes were completely dry after 12 months. In treatment-naïve eyes, the mean treatment interval was 12.7±6.4 weeks at 12 months. In pretreated eyes, the interval increased from 6.0±3.0 to 7.8±3.6 weeks (p<0.001). Over 12 months, 8.1±2.1 and 9.4±2.5 injections were administered to naïve and pretreated eyes, respectively (p<0.001). Of the five recorded AEs, two cases of non-infectious intraocular inflammation and one cerebrovascular event were reported.Conclusion Over 12 months, faricimab demonstrated good efficacy and safety in both treatment-naïve and pretreated eyes with DME. There was a reduction in CST and improved VA in treatment-naïve eyes and stable VA in pretreated eyes. The low number of AEs supports a favourable risk-benefit profile of faricimab in a real-world setting.",
  "authors": [
    {
      "affiliations": [
        "Department of Ophthalmology, Stadtspital Zurich Triemli, Zürich, Switzerland",
        "Spross Research Institute, Zurich, Switzerland"
      ],
      "name": "Amr Saad"
    },
    {
      "affiliations": [
        "Medical Retina & Clinical Research Department, Vista Klinik, Binningen, Switzerland",
        "University of Basel Faculty of Medicine, Basel, Switzerland"
      ],
      "name": "Christina Plasencia"
    },
    {
      "affiliations": [
        "Berner Augenklinik am Lindenhofspital, Bern, Switzerland",
        "Department of Ophthalmology, Inselspital University Hospital Bern, Bern, Switzerland",
        "Swiss Eye Institute, Bern, Switzerland"
      ],
      "name": "Justus Garweg"
    },
    {
      "affiliations": [
        "Swiss Eye Institute, Bern, Switzerland"
      ],
      "name": "Isabel Barbara Pfister"
    },
    {
      "affiliations": [
        "Ophthalmology, Inselspital, University Hospital Bern, Bern, Switzerland",
        "Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA",
        "Augenärztepraxisgemeinschaft Gutblick AG, Pfäffikon, Switzerland"
      ],
      "name": "Marion R Munk"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Jules Gonin Eye Hospital, Lausanne, Switzerland",
        "Department of Surgical Sciences, University of Torino, Torino, Italy"
      ],
      "name": "Chiara Maria Eandi"
    },
    {
      "affiliations": [
        "Universitatsspital Zurich Augenklinik und Poliklinik, Zurich, Switzerland"
      ],
      "name": "Sandrine Anne Zweifel"
    },
    {
      "affiliations": [
        "Ophthalmology, Institute of Clinical Neurosciences of Southern Switzerland, Lugano, Switzerland",
        "Faculty of Biomedical Sciences, University of Southern Switzerland, Lugano, Switzerland"
      ],
      "name": "Gabriela Grimaldi"
    },
    {
      "affiliations": [
        "Research Center, Swiss Visio Montchoisi, Lausanne, Switzerland"
      ],
      "name": "Nicolò Bartolomeo"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Inselspital University Hospital Bern, Bern, Switzerland",
        "Augenärztepraxisgemeinschaft Gutblick AG, Pfäffikon, Switzerland"
      ],
      "name": "Richard Stillenmunkes"
    },
    {
      "affiliations": [
        "Swiss Eye Institute, Bern, Switzerland"
      ],
      "name": "Christin Schild"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Jules Gonin Eye Hospital, Lausanne, Switzerland"
      ],
      "name": "Jennifer Cattaneo"
    },
    {
      "affiliations": [
        "Universitatsspital Zurich Augenklinik und Poliklinik, Zurich, Switzerland"
      ],
      "name": "Felix Gabathuler"
    },
    {
      "affiliations": [
        "Ophthalmology, Institute of Clinical Neurosciences of Southern Switzerland, Lugano, Switzerland",
        "Faculty of Biomedical Sciences, University of Southern Switzerland, Lugano, Switzerland"
      ],
      "name": "Moreno Menghini"
    },
    {
      "affiliations": [
        "Research Center, Swiss Visio Montchoisi, Lausanne, Switzerland"
      ],
      "name": "Aude Ambersin"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, University of Basel, Basel, Switzerland"
      ],
      "name": "Jacqueline Froehlich"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Kantonsspital St Gallen, St. Gallen, Switzerland",
        "University of Bern, Bern, Switzerland"
      ],
      "name": "Dmitri Artemiev"
    },
    {
      "affiliations": [
        "Pallas Kliniken AG, Olten, Switzerland",
        "Department of Ophthalmology, RWTH Aachen University, Aachen, Germany"
      ],
      "name": "Andreas Weinberger"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Stadtspital Zurich Triemli, Zürich, Switzerland",
        "Spross Research Institute, Zurich, Switzerland"
      ],
      "name": "Hamza Mohamed"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Stadtspital Zurich Triemli, Zürich, Switzerland",
        "Spross Research Institute, Zurich, Switzerland"
      ],
      "name": "Gabor Mark Somfai"
    },
    {
      "affiliations": [
        "Medical Retina & Clinical Research Department, Vista Klinik, Binningen, Switzerland",
        "University of Basel Faculty of Medicine, Basel, Switzerland"
      ],
      "name": "Katja Hatz"
    }
  ],
  "title": "First-year real-world outcomes of faricimab in clinically significant diabetic macular oedema: a Swiss retina research network report",
  "uid": "774d5223-fdce-5fb1-b7e4-9a6d6e5ec19d"
}