{
  "abstract": "Secondary intraocular lens (IOL) implantation is reported to increase glaucoma risk in paediatric patients. This study aimed to determine the incidence and risk factors for glaucoma onset or progression in children and young adults undergoing secondary IOL implantation.Retrospective cohort study of secondary IOL implantation following paediatric cataract surgery at Moorfields Eye Hospital (2017–2025). Anterior chamber IOLs and retinal pathology were excluded. Primary outcome measures included intraocular pressure (IOP), optic disc (OD) appearance and escalation in glaucoma management (surgery or eyedrops).57 eyes were included, 30 paediatric (aged 0–16) and 27 young adult (aged 17–30). Mean follow-up was 36.5 months (SD +/- 33.67). Cataract aetiology was congenital (49%), uveitic (26%) and traumatic (25%). IOL position was ciliary sulcus (68%), capsular bag (19%) and scleral-fixated (12%). 21 eyes (37%) had pre-existing glaucoma. In all patients, IOP remained normal/well-controlled post IOL implantation. 14 eyes (25%) had worsening OD appearance and 11 eyes (19%) required escalated glaucoma management (7% eyedrops, 9% surgery, 4% both). All but one of these had pre-existing glaucoma. 71% of eyes with pre-existing glaucoma had progression, compared to 3% of eyes without pre-existing glaucoma (relative risk=25.71; p<0.001).In patients having secondary IOL insertion there was a statistically significant increase in relative risk of glaucoma progression in patients with pre-existing glaucoma. Patients with congenital or traumatic cataract, without pre-existing glaucoma, rarely developed glaucoma post-operatively. No difference in glaucoma risk was found between age groups.We recommend close monitoring of patients with pre-existing glaucoma after secondary IOL insertion.",
  "authors": [
    {
      "affiliations": [
        "Moorfields Eye Hospital, London, UK"
      ],
      "name": "Victoria Barnett"
    },
    {
      "affiliations": [
        "Moorfields Eye Hospital, London, UK"
      ],
      "name": "Christopher Ashton"
    },
    {
      "affiliations": [
        "Moorfields Eye Hospital, London, UK"
      ],
      "name": "Lucy Barker"
    }
  ],
  "title": "130312 Does secondary intraocular lens implantation increase the risk of glaucoma in aphakic patients who underwent cataract surgery in childhood?",
  "uid": "30553e05-f0c8-55cd-853b-026aaf1f34a6"
}