{
  "abstract": "Peripapillary hyper-reflective ovoid mass-like structures (PHOMS) are commonly seen in optical coherence tomography (OCT) imaging of the optic nerve head. Its pathogenesis is poorly understood and is often seen in children presenting with possible optic nerve swelling. We aim to review the prevalence of PHOMS in children and the co-existence of PHOMS in ocular pathologies.A systematic review was conducted on 15th March 2025 on PubMed, EMBASE and Web of Science. To estimate the pooled prevalence of PHOMS, random effects meta-analyses were conducted.Two studies provided the prevalence of PHOMS in normal children (n=1572). The pooled prevalence was 4.91% (95% CI: 0.51–12.44%). Four studies looked at children referred for suspected optic nerve swelling. Among this cohort (n=497), the prevalence of PHOMS was 82.6% (95% CI 59.0–98.1%). Three studies reported the co-existence of PHOMS in children with optic disc drusen (n=164). PHOMS were identified in 90.2% (95% CI 73.3–99.7%) of eyes with disc drusen. One study provided the prevalence of PHOMS in children with papilloedema (180/308 eyes; 58.4%) and optic neuritis (9/59 eyes; 15.3%). Among Danish myopic children, a study found the prevalence of PHOMS to be 19.6% (38/194 eyes) while another study looking at Chinese children reported a prevalence of 66.3% (67/101 eyes). One study determined the prevalence of PHOMS in children with craniosynostosis to be 22.0% (n=118).This review shows that PHOMS are commonly seen in both normal and pathological eyes. Therefore, when PHOMS are identified on OCT imaging, other co-existing ocular pathologies should also be carefully considered.",
  "authors": [
    {
      "affiliations": [
        "Ng Teng Fong General Hospital, Singapore"
      ],
      "name": "Kirsten Wong"
    },
    {
      "affiliations": [
        "Ng Teng Fong General Hospital, Singapore"
      ],
      "name": "Weijen Tan"
    }
  ],
  "title": "130324 Prevalence of peripapillary hyperreflective ovoid mass-like structures in children: a systematic review and meta-analysis",
  "uid": "208cbd01-641a-5055-84de-d25ea1ab3166"
}