{
  "abstract": "Purpose The deepLive™ system, developed by DAMAE MEDICAL and based on line-field confocal optical coherence tomography (LC-OCT), is widely used in dermatology for non-invasive imaging of skin structures. This study aims at evaluating the safety, in a preclinical study, of deepLive for potential ophthalmic applications, specifically targeting the conjunctiva and the anterior segment of the eye.Methods Five 14-week-old New Zealand White (NZW) rabbits were used. LC-OCT imaging of the cornea along the optical axis was performed for 5 to 10 minutes with a laser power output of approximately 13 mW (higher than in the commercially available dermatological systems to test a worst-case situation). The objective was in contact with the ocular surface. The laser source was a supercontinuum broadband laser with nanoseconds pulses and MHz repetition rate, with an output spectrum spanning from 650 nm to 950 nm. Clinical evaluations were conducted at baseline (Day D0) and postoperatively on D7 and 14, including slit-lamp imaging of the cornea and lens, retinal imaging with a veterinary fundus camera, and intraocular pressure (IOP) measurement using a rebound tonometer. At the end of the study, ocular tissues were collected for histological examination using a standardized grading system.Results No sign of corneal inflammation was observed in any of the rabbits during the study. At D14, epithelial integrity was confirmed to be intact through fluorescein staining. No defects were detected in the retina along the optical axis, and no lens opacification occurred over the 14-day period. The LC-OCT allowed providing pseudo-histological images of all corneal and conjunctival layers.Conclusion LC-OCT imaging demonstrated no adverse effects on ocular tissues in this in vivo study. These findings support its great potential in ophthalmic applications, specifically for imaging the sclera, conjunctiva and cornea, without causing damage to ocular structures.",
  "authors": [
    {
      "affiliations": [
        "Biology, Engineering and Imaging for Ophthalmology, BO, Faculty of Medicine, Health Innovation Campus, Jean Monnet University, Saint-Etienne, France"
      ],
      "name": "Emmanuel Crouzet"
    }
  ],
  "title": "5.3. Safety assessment of line-field confocal-OCT imaging for ophtalmic applications: an in vivo study on NZW Rabbits",
  "uid": "942e2138-9ad5-5dc7-b6d8-0a096c81cb01"
}