{
  "abstract": "Objective Glaucoma is a common neurodegenerative disease resulting in irreversible blindness. This study investigates whether fucoxanthin can safeguard retinal ganglion cells (RGCs) by modulating Parkin-mediated mitophagy in experimental glaucoma.Methods An experimental glaucomatous model was induced in Sprague-Dawley rats via translimbal laser photocoagulation. Intraocular pressure (IOP) was monitored using a Tonolab tonometer. RGC survival was evaluated through FluoroGold labelling. Retinal and optic nerve samples were analysed at 3 days and 2 weeks post-IOP elevation for mitochondrial morphology and gene/protein expression using immunohistochemistry and molecular assays.Results Results demonstrated that mitophagy was acutely overactivated in the short term and impaired over the long term in ocular hypertensive rats. Fucoxanthin intravitreal administration enhanced RGC survival and Bcl-2 expression while reducing Bax and glial fibrillar acidic protein levels. During acute IOP elevation, fucoxanthin curtailed Parkin expression and mitophagosome formation, mitigating excessive mitophagy. Under prolonged IOP elevation, it elevated mitophagy-related proteins and restored mitophagy function, contributing to damaged mitochondrial clearance.Conclusion Fucoxanthin exerts neuroprotective effects in experimental glaucoma by modulating Parkin-mediated mitophagy. This highlights the therapeutic potential of maintaining mitophagy homeostasis for glaucoma treatment.",
  "authors": [
    {
      "affiliations": [
        "Department of Ophthalmology, The Affiliated People’s Hospital of Ningbo University, Ningbo, Zhejiang, China",
        "Ningbo Clinical Research Center for Ophthalmology, Ningbo, Zhejiang, China",
        "Ningbo Key Laboratory for Neuroretinopathy Medical Research, Ningbo, Zhejiang, China",
        "The Eye Hospital of Wenzhou Medical University (Ningbo Branch), Ningbo, Zhejiang, China"
      ],
      "name": "Haixia Ma"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, The Affiliated People’s Hospital of Ningbo University, Ningbo, Zhejiang, China",
        "Ningbo Clinical Research Center for Ophthalmology, Ningbo, Zhejiang, China",
        "Ningbo Key Laboratory for Neuroretinopathy Medical Research, Ningbo, Zhejiang, China",
        "The Eye Hospital of Wenzhou Medical University (Ningbo Branch), Ningbo, Zhejiang, China"
      ],
      "name": "Xinxin Hu"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, The Affiliated People’s Hospital of Ningbo University, Ningbo, Zhejiang, China",
        "Ningbo Clinical Research Center for Ophthalmology, Ningbo, Zhejiang, China",
        "Ningbo Key Laboratory for Neuroretinopathy Medical Research, Ningbo, Zhejiang, China",
        "The Eye Hospital of Wenzhou Medical University (Ningbo Branch), Ningbo, Zhejiang, China"
      ],
      "name": "Juntao Zhang"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, The Affiliated People’s Hospital of Ningbo University, Ningbo, Zhejiang, China",
        "Ningbo Clinical Research Center for Ophthalmology, Ningbo, Zhejiang, China",
        "Ningbo Key Laboratory for Neuroretinopathy Medical Research, Ningbo, Zhejiang, China",
        "The Eye Hospital of Wenzhou Medical University (Ningbo Branch), Ningbo, Zhejiang, China"
      ],
      "name": "Wei Lian"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, The Affiliated People’s Hospital of Ningbo University, Ningbo, Zhejiang, China",
        "Ningbo Clinical Research Center for Ophthalmology, Ningbo, Zhejiang, China",
        "Ningbo Key Laboratory for Neuroretinopathy Medical Research, Ningbo, Zhejiang, China",
        "The Eye Hospital of Wenzhou Medical University (Ningbo Branch), Ningbo, Zhejiang, China"
      ],
      "name": "Dandan Wang"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, The Affiliated People’s Hospital of Ningbo University, Ningbo, Zhejiang, China",
        "Ningbo Clinical Research Center for Ophthalmology, Ningbo, Zhejiang, China",
        "Ningbo Key Laboratory for Neuroretinopathy Medical Research, Ningbo, Zhejiang, China",
        "The Eye Hospital of Wenzhou Medical University (Ningbo Branch), Ningbo, Zhejiang, China"
      ],
      "name": "Lifang Zhang"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, The Affiliated People’s Hospital of Ningbo University, Ningbo, Zhejiang, China",
        "Ningbo Clinical Research Center for Ophthalmology, Ningbo, Zhejiang, China",
        "Ningbo Key Laboratory for Neuroretinopathy Medical Research, Ningbo, Zhejiang, China",
        "The Eye Hospital of Wenzhou Medical University (Ningbo Branch), Ningbo, Zhejiang, China"
      ],
      "name": "Qinkang Lu"
    }
  ],
  "title": "Fucoxanthin protects retinal ganglion cells and regulates Parkin-mediated mitophagy in experimental glaucoma",
  "uid": "b2959a9e-d7f8-5185-b914-e2f42bb63ffd"
}