{
  "abstract": "Objective Respiratory syncytial virus (RSV) is an important viral pathogen in children, older adults and adults with certain high-risk conditions. In our prospective community-based cohort study of adults 50 years and older before the COVID-19 pandemic, the incidence of RSV acute respiratory infection (ARI) was 48.6 cases/1000 person-years (PY), which decreased to near zero during the COVID-19 pandemic. Our objective was to determine the incidence of RSV-ARI during the 2 years following the initial phase of the pandemic (2021–2022 and 2022–2023).Design This is a community-based prospective cohort study.Setting Adults living in southeast Minnesota from October 2021 to September 2022 (year 3) and October 2022 to September 2023 (year 4).Participants Adults≥50 years (n=2500).Primary and secondary outcomes We calculated incidence and attack rates for RSV-ARI as primary outcome and reported hospitalisations, pneumonia and death following ARI as secondary outcome.Results There were 2500 participants in the study with a mean age of 68.2 years (SD 9.3) at the start of year 3. Participants were predominantly female (60%), non-Hispanic white (96%) and residing in urban areas (76%). The incidence rate of RSV-ARI was 6.12/1000 PY (95% CI 3.42 to 10.09) in 2021–2022 and 16.40/1000 PY (95% CI 11.66 to 22.42) in 2022–2023. We noted higher attack rates of RSV-ARI during the winter months. There were no hospitalisations, pneumonia or deaths within 30 days of RSV-ARI.Conclusions Compared with the period before the COVID-19 pandemic, RSV-ARI incidence was lower in both 2021–2022 and 2022–2023 periods. In 2022–2023, the incidence increased 2.7-fold compared with the 2021–2022 period. The observed incidence rates, particularly the significant increase in the most recent season, underscore the continued public health relevance of RSV-ARI and support the rationale for ongoing RSV vaccination efforts to mitigate its overall burden in the population.",
  "authors": [
    {
      "affiliations": [
        "Division of Primary Care Internal Medicine, Geriatrics and Palliative Care, Mayo Clinic Rochester, Rochester, Minnesota, USA"
      ],
      "name": "Paul Y Takahashi"
    },
    {
      "affiliations": [
        "GSK, Wavre, Belgium"
      ],
      "name": "Pouya Saeedi"
    },
    {
      "affiliations": [
        "Division of Community Pediatrics and Adolescent Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA"
      ],
      "name": "Chung-Il Wi"
    },
    {
      "affiliations": [
        "Divisons of Hospital Internal Medicine and Endocrinology and the Kogod Center on Aging, Mayo Clinic Rochester, Rochester, Minnesota, USA"
      ],
      "name": "Robert J Pignolo"
    },
    {
      "affiliations": [
        "Division of Infectious Diseases, Mayo Clinic Florida, Jacksonville, Florida, USA"
      ],
      "name": "Wendelyn Bosch"
    },
    {
      "affiliations": [
        "Department of Quantitative Health Sciences, Mayo Clinic Rochester, Rochester, Minnesota, USA"
      ],
      "name": "Katherine S King"
    },
    {
      "affiliations": [
        "Department of Quantitative Health Sciences, Mayo Clinic Rochester, Rochester, Minnesota, USA"
      ],
      "name": "Joel Hickman"
    },
    {
      "affiliations": [
        "Department of Quantitative Health Sciences, Mayo Clinic Rochester, Rochester, Minnesota, USA"
      ],
      "name": "Euijung Ryu"
    },
    {
      "affiliations": [
        "Division of Community Pediatrics and Adolescent Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA"
      ],
      "name": "Traci Natoli"
    },
    {
      "affiliations": [
        "Division of Community Pediatrics and Adolescent Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA"
      ],
      "name": "Kathy Ihrke"
    },
    {
      "affiliations": [
        "Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Rochester, Minnesota, USA"
      ],
      "name": "Joseph Yao"
    },
    {
      "affiliations": [
        "Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Rochester, Minnesota, USA"
      ],
      "name": "Matthew Binnicker"
    },
    {
      "affiliations": [
        "Division of Community Pediatrics and Adolescent Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA"
      ],
      "name": "Steph Sieler"
    },
    {
      "affiliations": [
        "Division of Infectious Diseases, Mayo Clinic Arizona, Scottsdale, Arizona, USA"
      ],
      "name": "Lisa Speiser"
    },
    {
      "affiliations": [
        "Department of Family Medicine, Mayo Clinic Health System in Eau Claire, Eau Claire, Wisconsin, USA"
      ],
      "name": "Brandon Hidaka"
    },
    {
      "affiliations": [
        "GSK, Wavre, Belgium"
      ],
      "name": "Silvia Damaso"
    },
    {
      "affiliations": [
        "GSK, Wavre, Belgium"
      ],
      "name": "Jean-Yves Pircon"
    },
    {
      "affiliations": [
        "Division of Community Pediatrics and Adolescent Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA"
      ],
      "name": "Young Juhn"
    }
  ],
  "title": "Incidence of respiratory syncytial virus in adults ≥50 years during and following the COVID-19 pandemic in upper midwest USA: a community-based prospective cohort study",
  "uid": "d692cd26-f79b-514f-a3cc-2908e378fcc6"
}