{
  "abstract": "Introduction Stroke remains a leading cause of disability and mortality worldwide, with an urgent need for novel therapeutic strategies to improve recovery. Bupropion hydrochloride, a norepinephrine–dopamine reuptake inhibitor, may promote motor and cognitive recovery due to its unique mechanism of action. To evaluate the efficacy and safety of early adjunctive treatment with bupropion hydrochloride versus placebo on functional recovery in patients with acute ischaemic stroke.Methods and analysis BASE is an investigator-initiated, multicentre, randomised, double-blind, placebo-controlled trial. We plan to enrol 1054 eligible patients with acute ischaemic stroke (National Institutes of Health Stroke Scale (NIHSS) score 8–15, within 2–7 days after onset) from approximately 40 stroke centres across China. Participants will be randomly assigned (1:1) to receive either oral bupropion hydrochloride (75 mg two times per day) or matched placebo for 30 days, in addition to standard guideline-based care. The primary efficacy endpoint is the proportion of patients achieving a favourable functional outcome, defined as a modified Rankin Scale (mRS) score of 0–3 at 90 days. Key secondary endpoints include shifts in mRS scores, changes in NIHSS, Hamilton Depression Rating Scale (HAMD-17), Fugl-Meyer Motor Scale scores and quality of life (EQ-5D). Safety endpoints include mortality, vascular events and incidence of adverse events. Analyses will be performed on both the intention-to-treat and per-protocol populationsEthics and dissemination The study protocol was approved by the Ethics Committee of the First Affiliated Hospital of Chongqing Medical University (ID ZZ2025-747-01), and all participants will provide written informed consent. Results will be disseminated through peer-reviewed publications and conference presentations.Trial registry number ChiCTR2500105746 ( www.chictr.org.cn).",
  "authors": [
    {
      "affiliations": [
        "Department of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"
      ],
      "name": "Qisheng Cheng"
    },
    {
      "affiliations": [
        "Department of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"
      ],
      "name": "Yuxin Ran"
    },
    {
      "affiliations": [
        "Department of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"
      ],
      "name": "Dongfang Wang"
    },
    {
      "affiliations": [
        "Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"
      ],
      "name": "Wensong Yang"
    },
    {
      "affiliations": [
        "Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"
      ],
      "name": "Yiqing Shen"
    },
    {
      "affiliations": [
        "Department of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China",
        "Chongqing Municipal Clinical Evaluation and Research Center for Cardiovascular and Cerebrovascular Drugs and Devices (Materials), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"
      ],
      "name": "Yikun Ren"
    },
    {
      "affiliations": [
        "Department of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"
      ],
      "name": "Huiji Zhang"
    },
    {
      "affiliations": [
        "Department of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"
      ],
      "name": "Yajie Xiang"
    },
    {
      "affiliations": [
        "Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"
      ],
      "name": "Huan Wang"
    },
    {
      "affiliations": [
        "Department of Neurology, Chongqing University Three Gorges Hospital, Chongqing, China",
        "Chongqing Key Laboratory of Cerebrovascular Diseases, Chongqing University Three Gorges Hospital, Chongqing, China"
      ],
      "name": "Jing Wang"
    },
    {
      "affiliations": [
        "Department of Neurology, Chongqing University Three Gorges Hospital, Chongqing, China",
        "Chongqing Key Laboratory of Cerebrovascular Diseases, Chongqing University Three Gorges Hospital, Chongqing, China"
      ],
      "name": "Jing Guo"
    },
    {
      "affiliations": [
        "Department of Neurology, Chongqing University Three Gorges Hospital, Chongqing, China",
        "Chongqing Key Laboratory of Cerebrovascular Diseases, Chongqing University Three Gorges Hospital, Chongqing, China"
      ],
      "name": "Chuyue Wu"
    },
    {
      "affiliations": [
        "Department of Neurology, Chongqing University Three Gorges Hospital, Chongqing, China",
        "Chongqing Key Laboratory of Cerebrovascular Diseases, Chongqing University Three Gorges Hospital, Chongqing, China"
      ],
      "name": "Shengli Chen"
    },
    {
      "affiliations": [
        "Department of Neurology, The First People’s Hospital of Yibin, Yibin, China"
      ],
      "name": "Hao Li"
    },
    {
      "affiliations": [
        "Department of Neurology, Chongqing Traditional Chinese Medicine Hospital, Chongqing, China"
      ],
      "name": "Wei Li"
    },
    {
      "affiliations": [
        "Department of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"
      ],
      "name": "Pu Zhang"
    },
    {
      "affiliations": [
        "Department of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"
      ],
      "name": "Dan Liu"
    },
    {
      "affiliations": [
        "Department of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"
      ],
      "name": "Qian Zhou"
    },
    {
      "affiliations": [
        "Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"
      ],
      "name": "Qi Li"
    },
    {
      "affiliations": [
        "Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"
      ],
      "name": "Peng Zheng"
    },
    {
      "affiliations": [
        "Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"
      ],
      "name": "Zicheng Hu"
    },
    {
      "affiliations": [
        "Department of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"
      ],
      "name": "Peng Xie"
    }
  ],
  "title": "Protocol for BASE: a multicentre, double-blind, randomised, controlled trial of bupropion hydrochloride in acute ischaemic stroke in China",
  "uid": "40d2460a-0bfb-5b4e-a9f0-d03bc9d0f3ea"
}