{
  "abstract": "Introduction Diagnostic and therapeutic management of patients with periprosthetic joint infections (PJIs) remains challenging. This national cohort aims to describe the epidemiology, clinical phenotypes, management strategies and outcomes of patients with PJI.Methods and analysis This is a national, multicentre, prospective, longitudinal, observational cohort study of patients who underwent revision for PJI of the hip, knee, shoulder, elbow or ankle. Participating centres are university or non-university tertiary healthcare facilities located in Switzerland. Episodes include likely and confirmed PJI, as defined by the European Bone and Joint Infection Society criteria. During routine clinical visits around revision surgery, data are collected and patients are followed-up thereafter for a minimum of 2 years. The primary objective is infection outcome and secondary objectives include functional outcome and patient satisfaction and evaluation of host, infection, microbiological and treatment factors associated with treatment failure and poor functional outcomes, both in the overall population and across subgroups. A minimum of 329 patients would be needed to have sufficient statistical power to carry out these analyses.Ethics and dissemination Ethical approval has been granted by the Research Ethics Committee under protocol number 2021-01791. All patients provide written informed consent for inclusion in the study. Study findings will be disseminated through publications in peer-reviewed journals and presented at national and international conferences in the fields of orthopaedics, infectious diseases and microbiology. We plan to leverage the platform within the cohort to conduct future studies and interventional trials.Trial registration number NCT07473089.",
  "authors": [
    {
      "affiliations": [
        "Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"
      ],
      "name": "Micol Pallanza"
    },
    {
      "affiliations": [
        "Department of Orthopedics and Traumatology, Cantonal Hospital Aarau, Aarau, Switzerland"
      ],
      "name": "Atesch Ateschrang"
    },
    {
      "affiliations": [
        "Department of Infectious Diseases, University of Bern, Bern University Hospital, Bern, Switzerland",
        "Amsterdam University Medical Center, Department of Infectious Diseases, University of Amsterdam, Amsterdam, Netherlands",
        "Amsterdam Infection & Immunity Institute, Amsterdam, Netherlands"
      ],
      "name": "Anders Boyd"
    },
    {
      "affiliations": [
        "Department of Infectious Diseases and Infection Prevention, Cantonal Hospital Aarau, Aarau, Switzerland"
      ],
      "name": "Anna Conen"
    },
    {
      "affiliations": [
        "Department of Medicine, Infectious Diseases Division, University of Fribourg, Fribourg Cantonal Hospital (HFR), Fribourg, Switzerland"
      ],
      "name": "Antonios Kritikos"
    },
    {
      "affiliations": [
        "Department of Orthopedic Surgery and Traumatology, University of Fribourg, Fribourg Cantonal Hospital (HFR), Fribourg, Switzerland"
      ],
      "name": "Jonathan Laurençon"
    },
    {
      "affiliations": [
        "Department of Orthopaedic Surgery and Traumatology, Inselspital, University of Bern, Bern University Hospital, Bern, Switzerland"
      ],
      "name": "Emanuel Francis Liechti"
    },
    {
      "affiliations": [
        "Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"
      ],
      "name": "Sylvain Meylan"
    },
    {
      "affiliations": [
        "Division of Infectious Diseases, Department of Medicine, Geneva University Hospitals (HUG), Geneva, Switzerland",
        "Orthopedic Surgery Service, Geneva University Hospitals (HUG), Geneva, Switzerland"
      ],
      "name": "Truong-Thanh Pham"
    },
    {
      "affiliations": [
        "Service of Orthopaedics and Traumatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"
      ],
      "name": "Sylvain Steinmetz"
    },
    {
      "affiliations": [
        "Orthopedic Surgery Service, Geneva University Hospitals (HUG), Geneva, Switzerland"
      ],
      "name": "Domizio Suva"
    },
    {
      "affiliations": [
        "Department of Infectious Diseases, University of Bern, Bern University Hospital, Bern, Switzerland"
      ],
      "name": "Maria C Thurnheer"
    },
    {
      "affiliations": [
        "Department of Infectious Diseases, University of Bern, Bern University Hospital, Bern, Switzerland",
        "Department of Infectious Diseases, Royal Brisbane and Women’s Hospital, Herston, Queensland, Australia",
        "Centre for Immunology and Infection Control (CIIC), Queensland University of Technology, Brisbane, Queensland, Australia"
      ],
      "name": "Nora Renz"
    }
  ],
  "title": "Nationwide, multicentre, prospective periprosthetic joint infection cohort study: study protocol of the Swiss Revision Cohort (REVCO)",
  "uid": "4e27427c-c7b9-5b2e-8992-5ea5e04f98dd"
}