{
  "abstract": "Objectives To explore the outcomes among patients treated with TAVI (transcatheter aortic valve implantation) in the COMPARE-TAVI 1 trial by age groups and sex.Design Cohort study.Setting Three Danish university hospitals.Participants Patients treated with TAVI in the COMPARE-TAVI 1 trial (N=1030), 60 (5.8%), 337 (32.7%), 592 (57.5%) and 41 (4.0%) were in the four age groups, < 70, 70–79, 80–89 and 90+ years while 414 (40.2%) and 616 (59.8%) were of female and male sex.Interventions Transfemoral TAVI with balloon-expandable valves (Sapien or Myval) performed between June 2020 and November 2023.Outcome measures Post hoc analyses of trial secondary outcomes that include end-point committee-adjudicated outcomes.Results In the four age groups, 1-year mortality rates were 8.3%, 5.6%, 5.6% and 7.3% while it was 5.8% in both sexes. Across the four age groups, 1-year stroke rates were 6.7%, 1.8%, 3.2% and 4.9%, and 5.1% among females and 4.7% among males. In the four age groups, 1-year new pacemaker rates were 7.5%, 15%, 19% and 13% while it was 15% among females and 18% among males. Females had smaller annuli than males and their gradients were higher and the effective orifice area lower after TAVI but their frequency of prosthesis-patient mismatch was similar at 1 year.Conclusion While comorbidity levels varied between groups, clinical outcomes were similar across age groups and between sexes.Trial registration number NCT04443023.",
  "authors": [
    {
      "affiliations": [
        "Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark",
        "Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"
      ],
      "name": "Troels Thim"
    },
    {
      "affiliations": [
        "Department of Cardiology, Odense University Hospital, Odense, Region Syddanmark, Denmark"
      ],
      "name": "Henrik Nissen"
    },
    {
      "affiliations": [
        "Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark",
        "Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden"
      ],
      "name": "Phillip Freeman"
    },
    {
      "affiliations": [
        "Department of Cardiology, Odense University Hospital, Odense, Region Syddanmark, Denmark",
        "Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA"
      ],
      "name": "Jordi Sanchez Dahl"
    },
    {
      "affiliations": [
        "Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark",
        "Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"
      ],
      "name": "Evald Høj Christiansen"
    },
    {
      "affiliations": [
        "Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark"
      ],
      "name": "Ashkan Eftekhari"
    },
    {
      "affiliations": [
        "Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark"
      ],
      "name": "Bjarne Linde Nørgaard"
    },
    {
      "affiliations": [
        "Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark"
      ],
      "name": "Jonas Agerlund Povlsen"
    },
    {
      "affiliations": [
        "Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark"
      ],
      "name": "Steen Hvitfeldt Poulsen"
    },
    {
      "affiliations": [
        "Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark",
        "Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"
      ],
      "name": "Rebekka Vibjerg Jensen"
    },
    {
      "affiliations": [
        "Department of Cardiology, Odense University Hospital, Odense, Region Syddanmark, Denmark"
      ],
      "name": "Kristian Altern Øvrehus"
    },
    {
      "affiliations": [
        "Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark",
        "Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"
      ],
      "name": "Christian Juhl Terkelsen"
    }
  ],
  "title": "Transcatheter aortic valve implantation outcomes by patient age and sex in COMPARE-TAVI 1: a cohort study",
  "uid": "1c4019bd-3453-580e-9e2d-d2f3231fab43"
}