{
  "abstract": "Introduction Gynaecological cancers increasingly affect women of reproductive age, necessitating fertility-sparing treatments that balance oncological safety with reproductive potential. However, the long-term impact of these treatments on survivorship—specifically regarding sexual function, quality of life (QoL) and reproductive outcomes—remains understudied. LIFE-Repro is a prospective multicentre cohort study designed to evaluate these impacts in young female cancer survivors.Methods and analysis Between 2023 and 2027, eleven tertiary referral hospitals in Korea will recruit 200 patients aged ≤45 years with gynaecological cancers who have undergone fertility-sparing treatment. Participants will undergo baseline assessments followed by prospective follow-ups every 6 months. At each visit, patient-reported outcomes assessing sexual function, QoL and health status will be collected using a mobile application developed by the research team. The primary endpoint is the incidence of post-treatment sexual dysfunction measured by the Female Sexual Function Index–Korean version. Secondary endpoints include longitudinal changes in QoL, cancer recurrence, survival, pregnancy rates, live birth rates and premature menopause.Ethics and dissemination The study protocol was approved by the Institutional Review Board of Korea University Guro Hospital (2024GR0484). Results will be disseminated through peer-reviewed journals and conference presentations.Trial registration number KCT0009578.",
  "authors": [
    {
      "affiliations": [
        "Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea"
      ],
      "name": "Hyun-Woong Cho"
    },
    {
      "affiliations": [
        "Department of Obstetrics and Gynecology, Seoul National University, Seoul, South Korea"
      ],
      "name": "Se Ik Kim"
    },
    {
      "affiliations": [
        "Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea"
      ],
      "name": "Jeong-Yeol Park"
    },
    {
      "affiliations": [
        "Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea"
      ],
      "name": "Jung Bok Lee"
    },
    {
      "affiliations": [
        "Department of Obstetrics and Gynecology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea"
      ],
      "name": "Chel Hun Choi"
    },
    {
      "affiliations": [
        "Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, South Korea"
      ],
      "name": "Jung-Yun Lee"
    },
    {
      "affiliations": [
        "Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, South Korea"
      ],
      "name": "Bo Hyon Yun"
    },
    {
      "affiliations": [
        "Gynecologic Cancer Branch and Center for Uterine Cancer, National Cancer Center, Goyang-si, Gyeonggi-do, South Korea"
      ],
      "name": "Myong Cheol Lim"
    },
    {
      "affiliations": [
        "Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul St Mary’s Hospital, Seoul, South Korea"
      ],
      "name": "Sung-Jong Lee"
    },
    {
      "affiliations": [
        "Department of Obstetrics and Gynecology, College of Medicine, Korea University, Korea University Ansan Hospital, Ansan-si, South Korea"
      ],
      "name": "Kyung-Jin Min"
    },
    {
      "affiliations": [
        "Department of Obstetrics and Gynecology, The Catholic University of Korea, Daejeon St Mary’s Hospital, Daejeon, South Korea"
      ],
      "name": "Ji Geun Yoo"
    },
    {
      "affiliations": [
        "Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, South Korea"
      ],
      "name": "Dong Hoon Suh"
    },
    {
      "affiliations": [
        "Korean Society of Gynecologic Oncology, Seoul, South Korea"
      ],
      "name": "Yunjung Choi"
    },
    {
      "affiliations": [
        "Department of Obstetrics and Gynecology, Seoul National University, Seoul, South Korea"
      ],
      "name": "Jae-Weon Kim"
    }
  ],
  "title": "Impact of fertility preservation on quality of life, recurrence and reproductive success in young female cancer survivors: a Korean prospective multicentre cohort study protocol (LIFE-Repro)",
  "uid": "8363d40f-b920-55d9-b5d2-3a81c73600f6"
}