{
  "abstract": "Background In singleton pregnancies, gestational diabetes mellitus (GDM) causes maternal and neonatal complications. However, this association remains unclear in twin pregnancies. This study aimed to investigate the association between GDM and obstetric outcomes specifically in twin pregnancies.Methods A retrospective cohort study was conducted among women with twin pregnancies from January 2018 to July 2022. Maternal and neonatal outcomes were compared between women with and without GDM. Adjusted ORs, 95% CIs and SEs were estimated using logistic regression, adjusting for maternal age, prepregnancy body mass index and chorionicity.Results A total of 808 women (1616 neonates) were included in the study, of whom 178 had GDM, while 630 did not. GDM was found to be positively associated with (adjusted OR, (95% CI)) preterm birth (1.73 (1.17 to 2.54)), premature rupture of membranes (1.70 (1.03 to 2.79)) and hypothyroidism (2.58 (1.46 to 4.56)) in women with twin pregnancies. In regard to neonatal outcomes, GDM was positively associated with admission to neonatal ward (1.49 (1.13 to 1.96)), oxygen therapy (1.91 (1.45 to 2.52)), hyperbilirubinaemia (1.44 (1.08 to 1.90)), total use and prophylactic use of antibiotics (1.98 (1.17 to 3.33) and 1.88 (1.00 to 3.54), respectively). When stratified by gestational age, GDM remained positively associated with certain adverse outcomes exclusively in twin preterm infants.Conclusions Our study demonstrated that GDM is significantly associated with several adverse pregnancy outcomes in twin pregnancies, including hypothyroidism in pregnant women, preterm birth, admission to neonatal ward, oxygen therapy, hyperbilirubinaemia, the total and prophylactic use of antibiotics in twins. Specifically, in twin pregnancies, GDM may be more strongly associated with adverse outcomes in preterm infants than in term infants.",
  "authors": [
    {
      "affiliations": [
        "Division of Neonatology, Department of Pediatrics, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China",
        "Division of Neonatology, Department of Pediatrics, The Tenth Affiliated Hospital, Southern Medical University (Dongguan People’s Hospital), Dongguan, China"
      ],
      "name": "Liting Huang"
    },
    {
      "affiliations": [
        "Division of Neonatology, Department of Pediatrics, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China"
      ],
      "name": "Weipeng Xu"
    },
    {
      "affiliations": [
        "Division of Neonatology, Department of Pediatrics, Binhaiwan Central Hospital of Dongguan, Dongguan, China",
        "Dongguan Key Laboratory of Precision Diagnosis and Treatment for Critical Neonatal Diseases, Binhaiwan Central Hospital of Dongguan, Dongguan, China"
      ],
      "name": "Wei Li"
    },
    {
      "affiliations": [
        "Division of Neonatology, Department of Pediatrics, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China"
      ],
      "name": "Ya Jin"
    },
    {
      "affiliations": [
        "Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China"
      ],
      "name": "Sui Zhu"
    },
    {
      "affiliations": [
        "Division of Neonatology, Department of Pediatrics, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China"
      ],
      "name": "Guosheng Liu"
    },
    {
      "affiliations": [
        "Department of Neonatology, Guangdong Women and Children Hospital, Guangzhou, China"
      ],
      "name": "Chuan Nie"
    },
    {
      "affiliations": [
        "Division of Neonatology, Department of Pediatrics, The Tenth Affiliated Hospital, Southern Medical University (Dongguan People’s Hospital), Dongguan, China"
      ],
      "name": "Yueqin Ding"
    },
    {
      "affiliations": [
        "Division of Neonatology, Department of Pediatrics, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China"
      ],
      "name": "Bingxiao Li"
    },
    {
      "affiliations": [
        "Division of Neonatology, Department of Pediatrics, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China"
      ],
      "name": "Shasha Han"
    }
  ],
  "title": "Association between gestational diabetes mellitus and maternal and neonatal outcomes in twin pregnancies: a retrospective cohort study in Guangdong, China",
  "uid": "4724497b-2e97-5085-86e6-4b3951dede10"
}